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Current HIV Research

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ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

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Review Article

HIV Epidemiology and Prevention in Southwestern China: Trends from 1996-2017

Author(s): Huanhuan Chen, Liuhong Luo, Stephen W. Pan, Guanghua Lan, Qiuying Zhu, Jianjun Li, Jinhui Zhu, Yi Chen, Zhiyong Shen, Xianming Ge, Zhenzhu Tang, Hui Xing, Yiming Shao, Yuhua Ruan* and Wenmin Yang*

Volume 17, Issue 2, 2019

Page: [85 - 93] Pages: 9

DOI: 10.2174/1570162X17666190703163838

Abstract

The aim of this review is to describe long-term HIV epidemiology and prevention trends in Guangxi, a provincial-level region located along a major drug trafficking corridor in southwestern China. Between 1996 and 2006, HIV transmission in Guangxi was primarily fueled by Injection Drug Use (IDU). Since 2006, heterosexual sex has become the dominant mode of HIV transmission, followed by drug injection. Moreover, older, heterosexual adults appear to be at increased risk for HIV. The vast majority of new HIV cases are attributed to local HIV subtypes already circulating within Guangxi (93%), though imported subtypes are associated with younger age groups. Since 2011, HIV incidence in Guangxi has stabilized, due in part to HIV prevention efforts that include expanded HIV testing, antiretroviral treatment, and other intervention measures. Between 1996 and 2017, Guangxi, China experienced dramatic changes in the primary HIV transmission mode and at-risk age group. Due in part to local and National AIDS control and prevention campaigns, HIV incidence trends in Guangxi no longer appear to be increasing.

Keywords: HIV, transmission, injection drug use, sexual intercourse, antiretroviral therapy, prevention.

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[1]
Zhang Kl KL, Ma SJ. Epidemiology of HIV in China. BMJ 2002; 324(7341): 803-4.
[http://dx.doi.org/10.1136/bmj.324.7341.803] [PMID: 11934762]
[2]
UNAIDS Task Force on Drug Use and HIV. Drug use and HIV vulnerability: policy research study in Asia. Bangkok: UNAIDS Asia Pacific Intercountry Team 2000.
[3]
United Nations Office on Drugs and Crime. Global illicit drug trends 2003 Available from:.http://www.unodc.org
[4]
Lowinger P. The solution to narcotic addiction in the People’s Republic of China. Am J Drug Alcohol Abuse 1977; 4(2): 165-78.
[http://dx.doi.org/10.3109/00952997709002758] [PMID: 347925]
[5]
Thomas J. HIV/AIDS in China: Migrant population, drug injection responsible for increased transmission. AIDSlink 1998; (49): 12-4.
[PMID: 12293301]
[6]
China Ministry of Public Security.. Registered number of drug users in China updated through June of 2009.http://www.mps.gov.cn/n16/n1252/n1897/n2872/2077880.html
[7]
Chinese Center for Disease Control and Prevention.Analysis of HIV/STD epidemic in 2003. Beijing, China.
[8]
Chinese Center for Disease Control and Prevention. Analysis of HIV/STD epidemic in 2006. Beijing, China..
[9]
Chinese Center for Disease Control and Prevention. Analysis of HIV/STD epidemic in 2009. Beijing, China..
[10]
Chinese Center for Disease Control and Prevention. Analysis of HIV/STD epidemic in 2013. Beijing, China..
[11]
Ruan Y, Chen K, Hong K, et al. Community-based survey of HIV transmission modes among intravenous drug users in Sichuan, China. Sex Transm Dis 2004; 31(10): 623-7.
[http://dx.doi.org/10.1097/01.olq.0000140018.24262.4a] [PMID: 15389002]
[12]
Ruan Y, Qin G, Liu S, et al. HIV incidence and factors contributed to retention in a 12-month follow-up study of injection drug users in Sichuan Province, China. J Acquir Immune Defic Syndr 2005; 39(4): 459-63.
[http://dx.doi.org/10.1097/01.qai.0000152398.47025.0f] [PMID: 16010170]
[13]
Zhang Y, Shan H, Trizzino J, et al. Demographic characteristics and risk behaviors associated with HIV positive injecting drug users in Xinjiang, China. J Infect 2007; 54(3): 285-90.
[http://dx.doi.org/10.1016/j.jinf.2006.06.001] [PMID: 16831464]
[14]
Yin L, Qin G, Qian HZ, et al. Continued spread of HIV among injecting drug users in southern Sichuan Province, China. Harm Reduct J 2007; 4: 6.
[http://dx.doi.org/10.1186/1477-7517-4-6] [PMID: 17286871]
[15]
Zhang Y, Shan H, Trizzino J, et al. HIV incidence, retention rate, and baseline predictors of HIV incidence and retention in a prospective cohort study of injection drug users in Xinjiang, China. Int J Infect Dis 2007; 11(4): 318-23.
[http://dx.doi.org/10.1016/j.ijid.2006.09.001] [PMID: 17321184]
[16]
China NNCC. Annual report on drug control in China. Beijing, China: National Narcotics Control Commission 2002.
[17]
Ma Y, Li ZZ, Zhao SD. HIV was first discovered among IDUs in China. Zhonghua Liu Xing Bing Xue Za Zhi 1990; 11: 184-5.
[18]
Chinese Center for Disease Control and Prevention. Analysis of HIV/STD epidemic in 2002. Beijing, China.
[19]
Chinese Center for Disease Control and Prevention. Analysis of HIV/STD epidemic in 2004. Beijing, China..
[20]
Progress Report on AIDS. Prev Res 2005.
[21]
Zhang G, Zheng X, Liu W, et al. The survey of HIV prevalence among drug users in Guangxi, China Zhonghua Liu Xing Bing Xue Za Zhi 2000; 21(1): 15-6.
[22]
Lai S, Liu W, Chen J, et al. Changes in HIV-1 incidence in heroin users in Guangxi Province, China. J Acquir Immune Defic Syndr 2001; 26(4): 365-70.
[http://dx.doi.org/10.1097/00042560-200104010-00014] [PMID: 11317080]
[23]
Wei L, Chen J, Rodolph M, et al. HIV incidence, retention, and changes of high-risk behaviors among rural injection drug users in Guangxi, China. Subst Abus 2006; 27(4): 53-61.
[http://dx.doi.org/10.1300/J465v27n04_07] [PMID: 17347126]
[24]
Liu W, Chen J, Rodolph M, et al. HIV prevalence among injection drug users in rural Guangxi China. Addiction 2006; 101(10): 1493-1498 [Erratum in: Addiction. 2007; 102(5): 841]..
[http://dx.doi.org/ [http://10.1111/j.1360-0443.2006.01557.x] [PMID: 16968351]
[25]
Chinese Center for Disease Control and Prevention. Analysis of HIV/STD epidemic in 2011. Beijing, China..
[26]
Hu CKYG, Wang GC, Yun GL. Ten years of accomplishments in dermatology and venereology. Zhonghua Pifuke Zazhi 1959; 7: 290-4.
[27]
Hu CK, Ye GY, Chen ST. Control and eradication of syphilis in China. Beijing Science Conference. 167-77.
[28]
Gil VE, Wang MS, Anderson AF, Lin GM, Wu ZO. Prostitutes, prostitution and STD/HIV transmission in mainland China. Soc Sci Med 1996; 42(1): 141-52.
[http://dx.doi.org/10.1016/0277-9536(95)00064-X] [PMID: 8745115]
[29]
Qian HZ, Vermund SH, Wang N. Risk of HIV/AIDS in China: Subpopulations of special importance. Sex Transm Infect 2005; 81(6): 442-7.
[http://dx.doi.org/10.1136/sti.2004.014258] [PMID: 16326842]
[30]
Gong XD, Ye SZ, Zhang GC, et al. An epidemiologic analysis of sexually transmitted diseases in China in 2000. Chin J STD/AIDS Prev Cont 2001; 7: 131-4.
[31]
Shao Y, Jia Z. Challenges and opportunities for HIV/AIDS control in China. Lancet 2012; 379(9818): 804.
[http://dx.doi.org/10.1016/S0140-6736(12)60349-3] [PMID: 22386033]
[32]
Chen L, His JH, Wu X, et al. Disparities in HIV and syphilis prevalence and risk factors between older male clients with and without steady sex partners in southwestern rural China. BMC Infect Dis 2017; 17(1): 269.
[http://dx.doi.org/10.1186/s12879-017-2367-z] [PMID: 28403825]
[33]
Wu X, Huang H, Tang Z, et al. Aphrodisiac use and associated factors among oder male clients of low-cost female sex workers in southwestern rural areas of China. Sex Res Soc Policy 2016; 14(1): 1-10.
[34]
Tang Z, Wu X, Li G, et al. Aphrodisiac use associated with HIV infection in elderly male clients of low-cost commercial sex venues in Guangxi, China: a matched case-control study. PLoS One 2014; 9(10)e109452
[35]
Chen H, Wu X, Chen L, et al. Rapidly spreading HIV epidemic among older males and associated factors: A large-scale prospective cohort study in rural southwest China. Sex Transm Dis 2018. Epub ahead of print
[http://dx.doi.org/10.1097/OLQ.0000000000000957] [PMID: 30516723]
[36]
Lu H, Zhu Y, Wu X, et al. Study on the characteristics of commercial sexual behavior and the risk factors analysis of HIV infection among the old male clients, in Guangxi. Zhonghua Liu Xing Bing Xue Za Zhi 2015; 36(1): 31-4.
[37]
Xing J, Li YG, Tang W, et al. HIV/AIDS epidemic among older adults in China during 2005-2012: Results from trend and spatial analysis. Clin Infect Dis 2014; 59(2): e53-60.
[http://dx.doi.org/10.1093/cid/ciu214] [PMID: 24700658]
[38]
Liu H, Lin X, Xu Y, Chen S, Shi J, Morisky D. Emerging HIV epidemic among older adults in Nanning, China. AIDS Patient Care STDS 2012; 26(10): 565-7.
[http://dx.doi.org/10.1089/apc.2012.0227] [PMID: 22984779]
[39]
Chow EPF, Wilson DP, Zhang J, Jing J, Zhang L. Human immunodeficiency virus prevalence is increasing among men who have sex with men in China: Findings from a review and meta-analysis. Sex Transm Dis 2011; 38(9): 845-57.
[http://dx.doi.org/10.1097/OLQ.0b013e31821a4f43] [PMID: 21844741]
[40]
Zheng C, Xu JJ, Hu QH, et al. Commercial sex and risk of HIV, syphilis, and herpes simplex virus-2 among men who have sex with men in six Chinese cities. BMC Infect Dis 2016; 16(1): 765.
[http://dx.doi.org/10.1186/s12879-016-2130-x] [PMID: 28003032]
[41]
Xu JJ, Zhang C, Hu QH, et al. Recreational drug use and risks of HIV and sexually transmitted infections among Chinese men who have sex with men: Mediation through multiple sexual partnerships. BMC Infect Dis 2014; 14: 642.
[http://dx.doi.org/10.1186/s12879-014-0642-9] [PMID: 25443542]
[42]
Wang X, Lan G, Shen Z, et al. HIV and syphilis prevalence trends among men who have sex with men in Guangxi, China: Yearly cross-sectional surveys, 2008-2012. BMC Infect Dis 2014; 14: 367.
[http://dx.doi.org/10.1186/1471-2334-14-367] [PMID: 24993252]
[43]
Lou J, Cheng J, Li Y, et al. Comparison of different strategies for controlling HIV/AIDS spreading in MSM. Infect Dis Model 2018; 3: 293-300.
[http://dx.doi.org/[doi: 10.1016/j.idm.2018.10.002. eCollection 2018]
[44]
Li J, Peng L, Gilmour S, et al. A mathematical model of biomedical interventions for HIV prevention among men who have sex with men in China. BMC Infect Dis 2018; 18(1): 600.
[http://dx.doi.org/10.1186/s12879-018-3516-8] [PMID: 30486800]
[45]
Ruan Y, Li D, Li X, et al. Relationship between syphilis and HIV infections among men who have sex with men in Beijing, China. Sex Transm Dis 2007; 34(8): 592-7.
[http://dx.doi.org/10.1097/01.olq.0000253336.64324.ef] [PMID: 17325622]
[46]
Zhang X, Wang C, Hengwei W, et al. Risk factors of HIV infection and prevalence of co-infections among men who have sex with men in Beijing, China. AIDS 2007; 21(Suppl. 8): S53-7.
[http://dx.doi.org/10.1097/01.aids.0000304697.39637.4c] [PMID: 18172392]
[47]
Zhang X, Li S, Li X, et al. Characterization of HIV-1 subtypes and viral antiretroviral drug resistance in men who have sex with men in Beijing, China. AIDS 2007; 21(Suppl. 8): S59-65.
[http://dx.doi.org/10.1097/01.aids.0000304698.47261.b1] [PMID: 18172393]
[48]
Ruan Y, Luo F, Jia Y, et al. Risk factors for syphilis and prevalence of HIV, hepatitis B and C among men who have sex with men in Beijing, China: Implications for HIV prevention. AIDS Behav 2009; 13(4): 663-70.
[http://dx.doi.org/10.1007/s10461-008-9503-0] [PMID: 19082879]
[49]
Ruan Y, Jia Y, Zhang X, et al. Incidence of HIV-1, syphilis, hepatitis B, and hepatitis C virus infections and predictors associated with retention in a 12-month follow-up study among men who have sex with men in Beijing, China. J Acquir Immune Defic Syndr 2009; 52(5): 604-10.
[http://dx.doi.org/10.1097/QAI.0b013e3181b31f5c] [PMID: 19710617]
[50]
Li D, Jia Y, Ruan Y, et al. Correlates of incident infections for HIV, syphilis, and hepatitis B virus in a cohort of men who have sex with men in Beijing. AIDS Patient Care STDS 2010; 24(9): 595-602.
[http://dx.doi.org/10.1089/apc.2010.0083] [PMID: 20731610]
[51]
Ruan Y, Pan SW, Chamot E, et al. Sexual mixing patterns among social networks of HIV-positive and HIV-negative Beijing men who have sex with men: A multilevel comparison using roundtable network mapping. AIDS Care 2011; 23(8): 1014-25.
[http://dx.doi.org/10.1080/09540121.2010.542127] [PMID: 21400315]
[52]
Fan S, Lu H, Ma X, et al. Behavioral and serologic survey of men who have sex with men in Beijing, China: Implication for HIV intervention. AIDS Patient Care STDS 2012; 26(3): 148-55.
[http://dx.doi.org/10.1089/apc.2011.0277] [PMID: 22248333]
[53]
Li D, Li S, Liu Y, et al. HIV incidence among men who have sex with men in Beijing: A prospective cohort study. BMJ Open 2012; 2(6)e001829 doi: 10.1136/bmjopen-2012-001829.
[http://dx.doi.org/10.1136/bmjopen-2012-001829]
[54]
Lu H, Han Y, He X, et al. Alcohol use and HIV risk taking among Chinese MSM in Beijing. Drug Alcohol Depend 2013; 133(2): 317-23.
[http://dx.doi.org/10.1016/j.drugalcdep.2013.06.013] [PMID: 23876859]
[55]
Lou J, Blevins M, Ruan Y, et al. Modeling the impact on HIV incidence of combination prevention strategies among men who have sex with men in Beijing, China. PLoS One 2014; 9(3)e90985
[56]
Wu ZL, Guan GY, Zhao JH, et al. Dynamic characteristics and HIV infection of men who have sex with men from 2011 to 2017 in Yinchuan, Ningxia, China. Curr HIV Res 2018; 16(5): 364-73.
[http://dx.doi.org/10.2174/1570162X17666190119094035] [PMID: 30659545]
[57]
Wang N, Wu G, Lu R, et al. Investigating HIV infection and HIV incidence among chinese men who have sex with men with recent sexual debut, Chongqing, China, 2011. AIDS Behav 2016; 20(12): 2976-82.
[http://dx.doi.org/10.1007/s10461-016-1356-3] [PMID: 26979418]
[58]
Chinese Center for Disease Control and Prevention. Analysis of HIV/STD epidemic in 2007 Beijing, China.
[59]
Chinese Center for Disease Control and Prevention. Analysis of HIV/STD epidemic in 2015 Beijing, China.
[60]
Guanghua L, Yi C, Shuai T, et al. HIV, syphilis and behavioral risk factors among men who have sex with men in a drug-using area of southwestern China: Results of 3 cross-sectional surveys from 2013 to 2015. Medicine (Baltimore) 2018; 97(16)e0404
[http://dx.doi.org/10.1097/MD.0000000000010404] [PMID: 29668597]
[61]
Leluțiu-Weinberger C, Manu M, Ionescu F, et al. An mHealth intervention to improve young gay and bisexual men’s sexual, behavioral, and mental health in a structurally stigmatizing national context. JMIR Mhealth Uhealth 2018; 6(11)e183
[http://dx.doi.org/10.2196/mhealth.9283] [PMID: 30429117]
[62]
Tao J, Vermund SH, Lu H, et al. Impact of depression and anxiety on initiation of antiretroviral therapy among men who have sex with men with newly diagnosed HIV infections in China. AIDS Patient Care STDS 2017; 31(2): 96-104.
[http://dx.doi.org/10.1089/apc.2016.0214] [PMID: 28170305]
[63]
Tao J, Wang L, Kipp AM, et al. Relationship of stigma and depression among newly HIV-diagnosed Chinese men who have sex with men. AIDS Behav 2017; 21(1): 292-9.
[http://dx.doi.org/10.1007/s10461-016-1477-8] [PMID: 27376900]
[64]
Xia M, Kreiss JK, Holmes KK. Risk factors for HIV infection among drug users in Yunnan province, China: Association with intravenous drug use and protective effect of boiling reusable needles and syringes. AIDS 1994; 8(12): 1701-6.
[http://dx.doi.org/10.1097/00002030-199412000-00010] [PMID: 7888119]
[65]
Cheng H, Zhang J, Capizzi J, Young NL, Mastro TD. HIV-1 subtype E in Yunnan, China. Lancet 1994; 344(8927): 953-4.
[http://dx.doi.org/10.1016/S0140-6736(94)92304-3] [PMID: 7934363]
[66]
Luo CC, Tian C, Hu DJ, Kai M, Dondero T, Zheng X. HIV-1 subtype C in China. Lancet 1995; 345(8956): 1051-2.
[http://dx.doi.org/10.1016/S0140-6736(95)90792-0] [PMID: 7723522]
[67]
Yu XF, Chen J, Shao Y, Beyrer C, Lai S. Two subtypes of HIV-1 among injection-drug users in southern China. Lancet 1998; 351(9111): 1250.
[http://dx.doi.org/10.1016/S0140-6736(05)79316-8] [PMID: 9643749]
[68]
Kato K, Shiino T, Kusagawa S, et al. Genetic similarity of HIV type 1 subtype E in a recent outbreak among injecting drug users in northern Vietnam to strains in Guangxi Province of southern China. AIDS Res Hum Retroviruses 1999; 15(13): 1157-68.
[http://dx.doi.org/10.1089/088922299310250] [PMID: 10480629]
[69]
Yu XF, Chen J, Shao Y, et al. Emerging HIV infections with distinct subtypes of HIV-1 infection among injection drug users from geographically separate locations in Guangxi Province, China. J Acquir Immune Defic Syndr 1999; 22(2): 180-8.
[http://dx.doi.org/10.1097/00042560-199910010-00011] [PMID: 10843533]
[70]
Piyasirisilp S, McCutchan FE, Carr JK, et al. A recent outbreak of human immunodeficiency virus type 1 infection in southern China was initiated by two highly homogeneous, geographically separated strains, circulating recombinant form AE and a novel BC recombinant. J Virol 2000; 74(23): 11286-95.
[http://dx.doi.org/10.1128/JVI.74.23.11286-11295.2000] [PMID: 11070028]
[71]
Laeyendecker O, Zhang GW, Quinn TC, et al. Molecular epidemiology of HIV-1 subtypes in southern China. J Acquir Immune Defic Syndr 2005; 38(3): 356-62.
[PMID: 15735457]
[72]
Li L, Chen L, Liang S, et al. Subtype CRF01_AE dominate the sexually transmitted human immunodeficiency virus type 1 epidemic in Guangxi, China. J Med Virol 2013; 85(3): 388-95.
[http://dx.doi.org/10.1002/jmv.23360] [PMID: 23341369]
[73]
Liu W, Liang SJ, Yang JY, et al. Distribution of HIV-1 subtypes in Guangxi Zhuang Autonomous Region, 2008-2009. Zhonghua Liu Xing Bing Xue Za Zhi 2013; 34(1): 53-6.
[74]
Li J, Feng Y, Shen Z, et al. HIV-1 transmissions among recently infected individuals in southwest China are predominantly derived from circulating local strains. Sci Rep 2018; 8(1): 12831 Erratum in: Sci Rep 2018; 8(1). 17478..
[http://dx.doi.org/ [1[http://10.1038/s41598-018-29201-3] [PMID: 30150680]
[75]
Han M, Chen Q, Hao Y, et al. Design and implementation of a China comprehensive AIDS response programme (China CARES), 2003-08. Int J Epidemiol 2010; 39(Suppl. 2): ii47-55.
[http://dx.doi.org/10.1093/ije/dyq212] [PMID: 21113037]
[76]
Liu B, Sullivan SG, Wu Z. An evaluation of needle exchange programmes in China. AIDS 2007; 21(Suppl. 8): S123-8.
[http://dx.doi.org/10.1097/01.aids.0000304707.56670.cf] [PMID: 18172380]
[77]
Yin W, Hao Y, Sun X, et al. Scaling up the national methadone maintenance treatment program in China: Achievements and challenges. Int J Epidemiol 2010; 39(Suppl. 2): ii29-37.
[http://dx.doi.org/10.1093/ije/dyq210] [PMID: 21113034]
[78]
Rou K, Sullivan SG, Liu P, Wu Z. Scaling up prevention programmes to reduce the sexual transmission of HIV in China. Int J Epidemiol 2010; 39(Suppl. 2): ii38-46.
[http://dx.doi.org/10.1093/ije/dyq211] [PMID: 21113035]
[79]
Qian HZ, Hao C, Ruan Y, et al. Impact of methadone on drug use and risky sex in China. J Subst Abuse Treat 2008; 34(4): 391-7.
[http://dx.doi.org/10.1016/j.jsat.2007.07.002] [PMID: 17869049]
[80]
Ruan Y, Liang S, Zhu J, et al. Evaluation of harm reduction programs on seroincidence of HIV, hepatitis B and C, and syphilis among intravenous drug users in southwest China. Sex Transm Dis 2013; 40(4): 323-8.
[http://dx.doi.org/10.1097/OLQ.0b013e31827fd4d4] [PMID: 23486498]
[81]
Zhang L, Liang S, Lu W, et al. HIV, syphilis, and behavioral risk factors among female sex workers before and after implementation of harm reduction programs in a high drug-using area of China. PLoS One 2014; 8; 9(1): e84950.
[http://dx.doi.org/10.1371/journal.pone.0084950. eCollection 2014]
[82]
Zhang F, Dou Z, Ma Y, et al. Effect of earlier initiation of antiretroviral treatment and increased treatment coverage on HIV-related mortality in China: A national observational cohort study. Lancet Infect Dis 2011; 11(7): 516-24.
[http://dx.doi.org/10.1016/S1473-3099(11)70097-4] [PMID: 21600849]
[83]
Zhang F, Dou Z, Ma Y, et al. Five-year outcomes of the China national free antiretroviral treatment program. Ann Intern Med 2009; 18; 151(4): 241-51, W-52.
[http://dx.doi.org/10.7326/0003-4819-151-4-200908180-00006]
[84]
Zhang F. Manual of the National Free Antiretroviral Treatment. 1st ed. Beijing: People’s Medical Publishing House 2005.
[85]
Zhang F, Wang Y, Wang J, et al. Manual of the National Free Antiretroviral Treatment. 2nd ed. Beijing: People’s Medical Publishing House 2008.
[86]
Zhang F, Wang J, Wang FS, et al. Manual of the National Free Antiretroviral Treatment. 2nd ed. Beijing: People’s Medical Publishing House 2012.
[87]
Shen Z, Zhu Q, Tang Z, et al. Effects of CD4 Cell Counts and Viral Load Testing on Mortality Rates in Patients with HIV Infection Receiving Antiretroviral Treatment: An Observational Cohort Study in Rural Southwest China. Clin Infect Dis 2016; 63(1): 108-14.
[http://dx.doi.org/10.1093/cid/ciw146] [PMID: 27001800]
[88]
Zwahlen M, Harris R, May M, et al. Mortality of HIV-infected patients starting potent antiretroviral therapy: Comparison with the general population in nine industrialized countries. Int J Epidemiol 2009; 38(6): 1624-33.
[http://dx.doi.org/10.1093/ije/dyp306] [PMID: 19820106]
[89]
Zhang F, Dou Z, Yu L, et al. The effect of highly active antiretroviral therapy on mortality among HIV-infected former plasma donors in China. Clin Infect Dis 2008; 47(6): 825-33.
[http://dx.doi.org/10.1086/590945] [PMID: 18690805]
[90]
Zhao DC, Wen Y, Ma Y, et al. Expansion of China’s free antiretroviral treatment program. Chin Med J (Engl) 2012; 125(19): 3514-21.
[PMID: 23044316]
[91]
Antiretroviral Therapy for HIV Infection in Adults and Adolescents: . Recommendations for a Public Health Approach2010 Revision.
[http://dx.doi.org/www.who.int/hiv/pub/arv/adult2010/en/index.html]
[92]
The Joint United Nations Programme on HIV/AIDS. 90-90-90: An ambitious treatment target to help end the AIDS epidemic 2014.. http://www.unaids.org/en/resources/documents/2014/90–90–90
[93]
World Health Organization. Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV 2015.http://www.who.int/hiv/pub/guidelines/earlyrelease-arv/en/
[94]
Tang Z, Pan SW, Ruan Y, et al. Effects of high CD4 cell counts on death and attrition among HIV patients receiving antiretroviral treatment: an observational cohort study. Sci Rep 2017; 7(1): 3129.
[http://dx.doi.org/10.1038/s41598-017-03384-7] [PMID: 28600549]
[95]
Pan SW, Shen Z, Xing H, Ruan Y, Shao Y. High baseline CD4 counts and antiretroviral therapy cessation. Clin Infect Dis 2018; 67(4): 644.
[http://dx.doi.org/10.1093/cid/ciy131] [PMID: 29462265]
[96]
Guangxi Center for Disease Control and Prevention. Analysis of HIV/STD epidemic in. China: Guangxi 2017.
[97]
Chen H, Yang X, Zhu Q, et al. Treatment for HIV prevention study in southwestern areas of China. Infect Dis Model 2018; 3: 249-55.
[http://dx.doi.org/10.1016/j.idm.2018.09.007] [PMID: 30839859]
[98]
Liu P, Tang Z, Lan G, et al. Early antiretroviral therapy on reducing HIV transmission in China: Strengths, weaknesses and next focus of the program. Sci Rep 2018; 8(1): 3431.
[http://dx.doi.org/10.1038/s41598-018-21791-2] [PMID: 29467460]
[99]
Jordan MR, Bennett DE, Bertagnolio S, Gilks CF, Sutherland D. World Health Organization surveys to monitor HIV drug resistance prevention and associated factors in sentinel antiretroviral treatment sites. Antivir Ther (Lond) 2008; 13(Suppl. 2): 15-23.
[PMID: 18575188]
[100]
Wang X, Yang L, Li H, et al. Factors associated with HIV virologic failure among patients on HAART for one year at three sentinel surveillance sites in China. Curr HIV Res 2011; 9(2): 103-11.
[http://dx.doi.org/10.2174/157016211795569122] [PMID: 21361864]
[101]
Liang S, Shen Z, Yan J, et al. Low virologic failure and drug resistance among HIV-infected patients receiving hospital-based ART while care and outreach through community in Guangxi, China. Front Public Health 2015; 3: 244.
[102]
Li G, Liang S, Harrison TJ, et al. Prevalence of transmitted HIV-1 drug resistance remains low in Guangxi, China, eight years after scale-up of highly-active antiretroviral therapy. Intervirology 2014; 57(5): 270-6.
[http://dx.doi.org/10.1159/000362366] [PMID: 24994115]
[103]
Zhang J, Shen ZY, Li Z, et al. Genetic Characteristics of CRF01_AE among newly diagnosed HIV-1-infected 16- to 25-year olds in 3 geographic regions of Guangxi, China. Medicine (Baltimore) 2015; 94(21)e894
[http://dx.doi.org/10.1097/MD.0000000000000894] [PMID: 26020400]
[104]
The People’s Government of Guangxi Zhuang Autonomous Region. Implementation plan of Guangxi AIDS Conquering Project (2010-2014).. 2010.
[105]
Chen Y, Tang Z, Tang S, et al. Decreasing HIV, syphilis, and hepatitis C infection after a decade of harm reduction implementation among drug users in Southwestern Areas of China. J Stud Alcohol Drugs 2018; 79(2): 248-57.
[http://dx.doi.org/10.15288/jsad.2018.79.248] [PMID: 29553354]
[106]
Chen Y, Abraham Bussell S, Shen Z, et al. declining inconsistent condom use but increasing HIV and syphilis prevalence among older male clients of female sex workers: Analysis from sentinel surveillance sites (2010-2015), Guangxi, China. Medicine (Baltimore) 2016; 95(22)e3726
[http://dx.doi.org/10.1097/MD.0000000000003726] [PMID: 27258500]

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