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Review Article

了解急性呼吸窘迫综合征的基因治疗

卷 19, 期 2, 2019

页: [93 - 99] 页: 7

弟呕挨: 10.2174/1566523219666190702154817

价格: $65

摘要

急性呼吸窘迫综合征（ARDS）及其并发症对危重病人来说仍然是危及生命的条件。目前的治疗策略，例如俯卧位通气策略，一氧化氮吸入，限制性静脉输液管理和体外膜肺氧合（ECMO）对提高ARDS的死亡率没有太大贡献。对急性呼吸窘迫综合征的病理生理学的深入理解表明，基于基因的治疗可能是这种疾病的创新方法。许多科学家已经做出有益的尝试来调节ARDS的免疫应答基因，维持肺泡上皮细胞和内皮细胞的正常功能，并抑制ARDS的纤维化和增殖。仍然存在对有效肺基因治疗的限制，包括病毒载体的安全性和针对吸入颗粒的肺防御机制。在此，我们总结和回顾了急性呼吸窘迫综合征的基因治疗机制及其应用。

关键词: 基因治疗，急性呼吸窘迫综合征，炎症，病毒载体，非病毒载体，间充质干/基质细胞。

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