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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

An Efficient and Green Microwave-Assisted Synthesis of Quinoline Derivatives via Knoevengal Condensation

Author(s): Syed Tasqeeruddin*, Yahya Asiri and Jaber Abdullah Alsherhri

Volume 17, Issue 2, 2020

Page: [157 - 163] Pages: 7

DOI: 10.2174/1570178616666190618153721

Price: $65

Abstract

We have developed an efficient and green synthesis of quinoline derivatives using L-proline under Knoevenagel condensation. L-proline was found to be an efficient catalyst for the Knoevenagel condensation of substituted 2-aminoaryl ketones 1 with the active methylene compounds 2, affording quinolone derivatives 3. The reaction has been done under conventional as well as under microwave conditions. The latter procedure has been found to be much more efficient in terms of time and yield.

Keywords: L-proline, Knoevenagel condensation, substituted 2-arylketones, active methylene compounds, microwave irradiation, quinoline derivatives.

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