Cell Cycle Checkpoint Genes and Aneuploidy: A Short Review

Title: Cell Cycle Checkpoint Genes and Aneuploidy: A Short Review

Volume: 2 Issue: 2

Author(s): William G. Kearns and Johnson M. Liu

Affiliation:

Keywords: Aneuploidy, CELL CYCLE REGULATION, Cell Cycle Kinases, CENTRIOLE

Abstract: Checkpoints regulate the normal progression of the cell cycle. Disturbance in the normal function of these checkpoints can induce genomic instability, which is associated with cancer initiation. One such form of instability, aneuploidy, can result from alterations of cell cycle checkpoints, and can induce large imbalances in gene copy number. These imbalances could, in turn, alter the expression of gene products involved in cancer development.

Cite this article as:

Kearns G. William and Liu M. Johnson, Cell Cycle Checkpoint Genes and Aneuploidy: A Short Review, Current Genomics 2001; 2 (2) . https://dx.doi.org/10.2174/1389202013350931