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Review Article

偏头痛作为一种寻求更好的阿片类镇痛药的新兴策略

卷 27, 期 9, 2020

页: [1562 - 1575] 页: 14

弟呕挨: 10.2174/0929867326666190506103124

价格: $65

摘要

通过激活阿片受体发挥作用的吗啡及相关药物是缓解严重疼痛的最有效止痛药。 尽管它们产生了许多有害的副作用，但它们已经使用了数十年，因为迄今为止尚未找到替代方法。 阿片类药物研究的主要目的是了解阿片受体激动剂的作用机理并提高阿片类药物的治疗效用。 在寻求更安全和更有效的止痛药中，具有混合阿片样物质受体特征的类似物引起了极大的兴趣。 然而，最近有偏见的概念突显了一些配体能够差异地激活受体下游途径这一事实，这已成为设计用于临床应用的新型候选药物的一种新方法。 在这篇综述中，我们总结了关于肽和非肽类阿片样物质配体发展的最新知识，显示了近年来阿片类药物的药理学发展了多少。

关键词: 阿片受体，阿片肽，抗伤害感受活性，偏向激动作用，偏向因子，吗啡。

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