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Medicinal Chemistry

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ISSN (Online): 1875-6638

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Review Article

Recent Advances in Therapeutic Applications of Bisbenzimidazoles

Author(s): Smita Verma , Vishnuvardh Ravichandiran, Nihar Ranjan and Swaran J.S. Flora*

Volume 16, Issue 4, 2020

Page: [454 - 486] Pages: 33

DOI: 10.2174/1573406415666190416120801

Price: $65

Abstract

Nitrogen-containing heterocycles are one of the most common structural motifs in approximately 80% of the marketed drugs. Of these, benzimidazoles analogues are known to elicit a wide spectrum of pharmaceutical activities such as anticancer, antibacterial, antiparasitic, antiviral, antifungal as well as chemosensor effect. Based on the benzimidazole core fused heterocyclic compounds, crescent-shaped bisbenzimidazoles were developed which provided an early breakthrough in the sequence-specific DNA recognition. Over the years, a number of functional variations in the bisbenzimidazole core have led to the emergence of their unique properties and established them as versatile ligands against several classes of pathogens. The present review provides an overview of diverse pharmacological activities of the bisbenzimidazole analogues in the past decade with a brief account of its development through the years.

Keywords: Bisbenzimidazole, hoechst 33258, hoechst 33342, DNA binders, anticancer compounds, antibacterial compounds.

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