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Research Article

黄芩苷对鸭病毒性肝炎的疗效评价

卷 19, 期 5, 2019

页: [376 - 386] 页: 11

弟呕挨: 10.2174/1566524019666190405095301

价格: $65

摘要

背景：鸭甲型肝炎病毒1型（DHAV-1）引起的鸭病毒性肝炎（DVH）是鸭子的一种恶性疾病，在鸭业中造成经济损失。然而，临床上仍然没有针对DHAV-1的抗病毒药物。 目的：本研究旨在探讨黄芩苷的抗DHAV-1作用，黄芩苷是一种来自中药黄芩（黄芩）的黄酮类化合物。 方法：在这里，我们首先在体外和体内检测到它的抗DHAV-1能力。同时，测定了黄芩苷对DHAV-1繁殖的抑制作用。最后，我们测试并验证了黄芩苷对DVH疗效的抗氧化和免疫增强作用。 结果：黄芩苷具有抗DHAV-1作用。它改善了被DHAV-1感染的DEH的细胞活性，并减少了DEH中DHAV-1的繁殖。在黄芩苷处理下，DHAV-1感染雏鸭的死亡率降低，此外，这些雏鸭的DHAV-1水平和肝损伤明显减少或缓解。体外机制研究表明黄芩苷通过干扰病毒的复制和释放来抑制DHAV-1的繁殖。此外，体内机制研究表明黄芩苷的抗氧化和免疫增强能力，其在其对DVH的疗效中起关键作用。 结论：本研究可为开发黄芩苷作为抗DHAV-1药物的一种或一部分提供科学依据。

关键词: DHAV-1，黄芩苷，抗病毒，病毒繁殖，抗氧化，免疫增强。

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