Abstract
Cysteine proteases are widespread in nature. Their implication in numerous vital processes and pathologies make them highly attractive targets for drug design. The proper functioning and regulation of activity of cysteine proteases is a delicate balance of many factors, one of the most crucial being the protease inhibitors. In this review the basic principles of physiological protease inhibition by protein inhibitors are discussed with the focus on papain-like lysosomal cysteine proteases and the caspases, and their inhibitors.
Keywords: cysteine protease, protease inhibitor, protein inhibitor, caspase, papain like cystein protease
Current Pharmaceutical Design
Title: Regulating Cysteine Protease Activity: Essential Role of Protease Inhibitors As Guardians and Regulators
Volume: 8 Issue: 18
Author(s): Boris Turk, Dusan Turk and Guy S. Salvesen
Affiliation:
Keywords: cysteine protease, protease inhibitor, protein inhibitor, caspase, papain like cystein protease
Abstract: Cysteine proteases are widespread in nature. Their implication in numerous vital processes and pathologies make them highly attractive targets for drug design. The proper functioning and regulation of activity of cysteine proteases is a delicate balance of many factors, one of the most crucial being the protease inhibitors. In this review the basic principles of physiological protease inhibition by protein inhibitors are discussed with the focus on papain-like lysosomal cysteine proteases and the caspases, and their inhibitors.
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Cite this article as:
Turk Boris, Turk Dusan and Salvesen S. Guy, Regulating Cysteine Protease Activity: Essential Role of Protease Inhibitors As Guardians and Regulators, Current Pharmaceutical Design 2002; 8 (18) . https://dx.doi.org/10.2174/1381612023394124
DOI https://dx.doi.org/10.2174/1381612023394124 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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