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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

阿尔茨海默氏症遗传风险的细微差别显示非痴呆记忆衰老轨迹的差异预测：APOE基因型和性别的选择模式

卷 16, 期 4, 2019

页: [302 - 315] 页: 14

弟呕挨: 10.2174/1567205016666190315094452

价格: $65

摘要

背景：载脂蛋白E（APOE）是阿尔茨海默病（AD）的主要遗传风险因子，也是与非痴呆和认知功能受损老化相关的常见目标。 APOE提供了一个独特的机会来评估两个二分法比较和选定的APOE风险等级。一些证据表明，APOE效应可能因性别而异，并且尤其在与其他AD相关生物标志物（例如，血管健康）的相互作用中出现。 方法：非痴呆成人的纵向轨迹（n = 632,67％女性，法师= 68.9）占40年的衰老带。针对记忆表现和个体化记忆轨迹，测试了一系列潜在生长模型，以预测APOE和脉压（PP）之间的（缓和），按性别分层。分析（1）建立了对记忆轨迹的强有力的基准PP效应，（2）比较了替代二分组的预测（ε4-对ε4+，ε2-对ε2+），以及（3）通过分解的APOE基因型检查基于精确度的预测。 结果：更健康（更低）的PP与更好的记忆表现和更少的下降相关。因此，所有后续分析都是在PP效应和性别分层的互动环境中进行的。基于ε4的二分法不产生差异遗传预测。基于ε2的分析显示性别差异，包括对ε2阳性女性的选择性保护。探索性随访分解的APOE基因型分析表明对纯合子和杂合子雌性的选择性ε2保护作用。 结论：AD遗传风险的精确分析将促进对潜在机制的理解，并改善干预措施的个性化实施。

关键词: 载脂蛋白E，阿尔茨海默病，脉压，记忆衰老，性别差异，轨迹分析，维多利亚纵向研究。

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