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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Systematic Review Article

The Effects of Vitamin D Supplementation on Glycemic Control, Lipid Profiles and C-Reactive Protein Among Patients with Cardiovascular Disease: a Systematic Review and Meta-Analysis of Randomized Controlled Trials

Author(s): Vahidreza Ostadmohammadi, Alireza Milajerdi, Majid Ghayour-Mobarhan, Gordon Ferns, Mohsen Taghizadeh, Bita Badehnoosh, Hamed Mirzaei and Zatollah Asemi*

Volume 25, Issue 2, 2019

Page: [201 - 210] Pages: 10

DOI: 10.2174/1381612825666190308152943

Price: $65

Abstract

Background: Insulin resistance, dyslipidemia and chronic inflammation are important risk factors for cardiovascular diseases (CVD). Hence, vitamin D supplementation might be an appropriate approach to decrease the complications of CVD. This systematic review and meta-analysis aimed to determine the effects of vitamin D supplementation on glycemic control, lipid profiles, and C-reactive protein among patients with coronary artery disease.

Methods: Two independent authors systematically searched online databases including EMBASE, Scopus, Pub- Med, Cochrane Library, and Web of Science until 20th September 2018. Cochrane Collaboration risk of bias tool was applied to assess the methodological quality of included trials. The heterogeneity among the included studies was assessed using Cochran’s Q test and I-square (I2) statistic. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size.

Results: A total of eight trials (305 participants in the intervention group and 325 in placebo group) were included in the current meta-analysis. Pooling effect sizes from studies revealed a significant reduction in fasting glucose (WMD): -15.67; 95% CI: -29.32, -2.03), insulin concentrations (WMD: -3.53; 95% CI: -4.59, -2.46) and homeostatic model assessment of insulin resistance (WMD: -1.07; 95% CI: -1.49, -0.66), and significant increase in the quantitative insulin-sensitivity check index (WMD: 0.02; 95% CI: 0.01, 0.03) following the administration of vitamin D. In addition, pooled analysis revealed a significant increase in serum HDL-cholesterol concentrations following vitamin D therapy (WMD: 3.08; 95% CI: 1.42, 4.73). Additionally, vitamin D supplementation significantly reduced C-reactive protein (CRP) levels (WMD: -0.75; 95% CI: -1.28, -0.23).

Conclusion: This meta-analysis demonstrated the beneficial effects of vitamin D supplementation on improving glycemic control, HDL-cholesterol and CRP levels among patients with CVD, though it did not affect triglycerides, total- and LDL-cholesterol levels.

Keywords: Vitamin D, insulin resistance, lipid profiles, cardiovascular disease, meta-analysis, random controlled trials.

« Previous
[1]
GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016; 388: 1459-544.
[2]
Zhu Y, Xian X, Wang Z, et al. Research progress on the relationship between atherosclerosis and inflammation. Biomolecules 2018; 8.
[3]
Mannarino E, Pirro M. Molecular biology of atherosclerosisClin Cases Miner Bone Metab 2008; 5: 57-62.
[4]
Liu C, Guo Q, Lu M, Li Y. An experimental study on amelioration of dyslipidemia-induced atherosclesis by Clematichinenoside through regulating Peroxisome proliferator-activated receptor-alpha mediated apolipoprotein A-I, A-II and C-III. Eur J Pharmacol 2015; 761: 362-74.
[5]
Jacobson TA, Maki KC, Orringer CE, et al. National lipid association recommendations for patient-centered management of dyslipidemia: Part 2. J Clin Lipidol 2015; 9: S1-S122.
[6]
Fulcher J, O’Connell R, Voysey M, et al. Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials. Lancet 2015 ; 385: 1397-405.
[7]
Raygan F, Ostadmohammadi V, Asemi Z. The effects of probiotic and selenium co-supplementation on mental health parameters and metabolic profiles in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial. Clin Nutr 2018 ; pii: S0261-5614(18): 31219-6.
[8]
Raygan F, Rezavandi Z, Bahmani F, et al. The effects of probiotic supplementation on metabolic status in type 2 diabetic patients with coronary heart disease. Diabetol Metab Syndr 2018; 10: 51.
[9]
Apostolakis M, Armeni E, Bakas P, Lambrinoudaki I. Vitamin D and cardiovascular disease. Maturitas 2018; 115: 1-22.
[10]
Petchey WG, Hickman IJ, Duncan E, et al. The role of 25-hydroxyvitamin D deficiency in promoting insulin resistance and inflammation in patients with chronic kidney disease: a randomised controlled trial. BMC Nephrol 2009; 10: 41.
[11]
Jafari T, Fallah AA, Barani A. Effects of vitamin D on serum lipid profile in patients with type 2 diabetes: A meta-analysis of randomized controlled trials. Clin Nutr 2016; 35: 1259-68.
[12]
Li X, Liu Y, Zheng Y, Wang P, Zhang Y. The effect of vitamin D supplementation on glycemic control in type 2 diabetes patients: a systematic review and meta-analysis. Nutrients 2018; 10(3): E375.
[13]
Mansournia MA, Ostadmohammadi V, Doosti-Irani A, et al. The effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients: a systematic review and meta-analysis of randomized controlled trials. Horm Metab Res 2018; 50: 429-40.
[14]
Akbari M, Ostadmohammadi V, Lankarani KB, et al. The Effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress among women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Horm Metab Res 2018; 50: 271-9.
[15]
Akbari M, Moosazaheh M, Lankarani KB, et al. The Effects of vitamin D supplementation on glucose metabolism and lipid profiles in patients with gestational diabetes: a systematic review and meta-analysis of randomized controlled trials. Horm Metab Res 2017; 49: 647-53.
[16]
Farrokhian A, Raygan F, Bahmani F, et al. Long-Term vitamin D supplementation affects metabolic status in vitamin d-deficient type 2 diabetic patients with coronary artery disease. J Nutr 2017; 147: 384-9.
[17]
Wu Z, Wang T, Zhu S, Li L. Effects of vitamin D supplementation as an adjuvant therapy in coronary artery disease patientsScand Cardiovasc J 2016; 50: 9-16.
[18]
Mirhosseini N, Vatanparast H, Mazidi M, Kimball SM. The Effect of improved serum 25-hydroxyvitamin D status on glycemic control in diabetic patients: a meta-analysis. J Clin Endocrinol Metab 2017; 102: 3097-110.
[19]
Krul-Poel YH, Ter Wee MM, Lips P, Simsek S. Management of endocrine disease: The effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Eur J Endocrinol 2017; 176: R1-r14.
[20]
Lee CJ, Iyer G, Liu Y, et al. The effect of vitamin D supplementation on glucose metabolism in type 2 diabetes mellitus: A systematic review and meta-analysis of intervention studies. J Diabetes Complications 2017; 31: 1115-26.
[21]
Wu C, Qiu S, Zhu X, Li L. Vitamin D supplementation and glycemic control in type 2 diabetes patients: A systematic review and meta-analysis. Metabolism 2017; 73: 67-76.
[22]
Miller AM, Alcaraz Ruiz A, Borrayo Sanchez G, Almeida Gutierrez E, Vargas Guzman RM, Jauregui Aguilar R. Metabolic syndrome: clinical and angiographic impact on patients with acute coronary syndrome. Cir Cir 2010; 78: 113-20.
[23]
Anselmino M, Malmberg K, Ryden L, Ohrvik J. A gluco-metabolic risk index with cardiovascular risk stratification potential in patients with coronary artery disease. Diab Vasc Dis Res 2009; 6: 62-70.
[24]
Chagas CE, Borges MC, Martini LA, Rogero MM. Focus on vitamin D, inflammation and type 2 diabetes. Nutrients 2012; 4: 52-67.
[25]
Hewison M. An update on vitamin D and human immunity. Clin Endocrinol (Oxf) 2012; 76: 315-25.
[26]
Selvaraj P, Harishankar M, Afsal K, Vitamin D. Immuno-modulation and tuberculosis treatment. Can J Physiol Pharmacol 2015; 93: 377-84.
[27]
Jorde R, Grimnes G. Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids. Prog Lipid Res 2011; 50: 303-12.
[28]
Wang H, Xia N, Yang Y, Peng DQ. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis 2012; 11: 42.
[29]
Elam MB, Hunninghake DB, Davis KB, et al. Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial. JAMA 2000; 284: 1263-70.
[30]
Reid IR. Effects of calcium supplementation on circulating lipids: potential pharmacoeconomic implications. Drugs Aging 2004; 21: 7-17.
[31]
Rajpathak SN, Xue X, Wassertheil-Smoller S, et al. Effect of 5 y of calcium plus vitamin D supplementation on change in circulating lipids: results from the Women’s Health Initiative. Am J Clin Nutr 2010; 91: 894-9.
[32]
Bahrami LS, Sezavar Seyedi Jandaghi SH, Janani L, et al. Vitamin D supplementation and serum heat shock protein 60 levels in patients with coronary heart disease: a randomized clinical trialNutr Metab (Lond) 2018; 15: 56.
[33]
Raygan F, Ostadmohammadi V, Bahmani F, Asemi Z. The effects of vitamin D and probiotic co-supplementation on mental health parameters and metabolic status in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trialProg Neuropsychopharmacol Biol Psychiatry 2018; 84(Pt A): 50-.
[34]
Shaseb E, Tohidi M, Abbasinazari M, et al. The effect of a single dose of vitamin D on glycemic status and C-reactive protein levels in type 2 diabetic patients with ischemic heart disease: a randomized clinical trial. Acta Diabetol 2016; 53: 575-82.
[35]
Asemi Z, Raygan F, Bahmani F, et al. The effects of vitamin D, K and calcium co-supplementation on carotid intima-media thickness and metabolic status in overweight type 2 diabetic patients with CHD. Br J Nutr 2016; 116: 286-93.
[36]
Sokol SI, Srinivas V, Crandall JP, et al. The effects of vitamin D repletion on endothelial function and inflammation in patients with coronary artery disease. Vasc Med 2012; 17: 394-404.
[37]
Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P, Koerfer R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2006; 83: 754-9.

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