Abstract
N-Heterocyclic architectures are omnipresent in many bioactive natural products, synthetic drugs, and materials science, thus have evoked a vast research interest of academic, as well as industrial chemists. Recently, several efficient methods have been developed for the preparation of various nitrogen-containing compounds with in situ generated 1,2-diaza-1,3-dienes from the easily available precursors including α -haloketohydrazones, α-hydroxyl ketohydrazones, thiadiazole dioxides or their analogues, and other simple hydrazones. These methods are considered powerful tools in the synthesis of five-, six- and seven-membered ring heterocyclic compounds with good to excellent levels of conversions and selectivities. This review mainly summarizes recent advances on the chemistry of construction of versatile N-heterocycles from in situ generated 1,2-diaza-1,3- dienes and presents an extensive summary of the application scopes and limitations of the corresponding cyclization reactions. Moreover, enantioselective approaches are also covered.
Keywords: 1, 2-Diaza-1, 3-dienes, azoalkanes, N-Heterocycles, cyclization reactions, annulations, Aza-Diels-Alder reaction.
Graphical Abstract
[1]
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Call for Papers in Thematic Issues
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Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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