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Review Article

小细胞肺癌的化疗耐药分子机制

卷 19, 期 3, 2019

页: [157 - 163] 页: 7

弟呕挨: 10.2174/1566524019666190226104909

价格: $65

摘要

小细胞肺癌（SCLC）的恶性程度在所有肺癌类型中最高。 其特点是生长迅速，早期发生远处转移，生存率低，最初对化疗和放疗敏感。 然而，由于化疗耐药性，大多数患者最终复发或疾病进展。 由于缺乏有效的二线治疗，SCLC患者的预后通常较差。 对于新疗法的开发，有必要了解SCLC中化疗耐药的机制。 该机制很复杂，因为多种因素可能导致化疗耐药。 讨论了触发SCLC细胞化学疗法抗性表型形成的多个事件的概述。

关键词: 小细胞肺癌，化疗耐药，多药耐药，细胞内酶系统，细胞凋亡逃逸，细胞修复系统，癌症干细胞。

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