Abstract
Background: CdSe QDs, synthesized using a green micro-emulsion method, have been evaluated for their potential in inducing HL-60 differentiation by employing various biochemical assays and as cellular imaging agents.
Methods: CdSe QDs have been found to effectively induce differentiation with lower rate of cell apoptosis as compared with the positive control (DMSO).
Results: Our results exhibit effective induction of HL-60 differentiation by CdSe QDs implicating their therapeutic role in cancerous cells in addition to their usual application as cell-imaging agents.
Conclusion: Our studies report that the chemo-preventive properties of CdSe exhibit great potential and further tailored-synthesis and cell-differen-tiations studies have a promising future in the preventive treatment of HL60 cancerous tissue.
Keywords: CdSe, quantum dots, microemulsion, HL60, cell differentiation, cell death, nanomedicine.
Graphical Abstract
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