[1]
Ahmad, A.; Husain, A.; Mujeeb, M.; Khan, S.A.; Najmi, A.K.; Siddique, N.A.; Damanhouri, Z.A.; Anwar, F. A review on therapeutic potential of Nigella sativa. Asian Pac. J. Trop. Biomed., 2013, 3(5), 337-352.
[2]
Levekar, G.; Chandra, K.; Dhar, B.; Mangal, A.; Dabur, R.; Gurav, A.M.; Yelne, M.; Joseph, G.; Chaudhari, B.; Mandal, T.K. Database on medicinal plants used in Ayurveda and Siddha. CCRAS, 2007, 8, 522-531.
[3]
Goreja, W. Black seed: Nature’s miracle remedy; Karger Publishers, 2003.
[4]
Bakathir, H.A.; Abbas, N.A. Detection of the antibacterial effect of Nigella sativa ground seedswith water. Afr. J. Tradit. Complement. Altern. Med., 2011, 8(2), 159-164.
[5]
Bita, A.; Rosu, A.; Calina, D.; Rosu, L.; Zlatian, O.; Dindere, C.; Simionescu, A. An alternative treatment for Candida infections with Nigella sativa extracts. Eur. J. Hosp. Pharm. Sci. Pract., 2012, 19(2), 162-162.
[6]
Umar, S.; Zargan, J.; Umar, K.; Ahmad, S.; Katiyar, C.K.; Khan, H.A. Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats. Chem. Biol. Interact., 2012, 197(1), 40-46.
[7]
Abdelmeguid, N.E.; Fakhoury, R.; Kamal, S.M.; Al Wafai, R.J. Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β‐cells of streptozotocin‐induced diabetic rats. J. Diabetes, 2010, 2(4), 256-266.
[8]
Salem, M.; Alenzi, F.; Attia, W. Thymoquinone, the active ingredient of Nigella sativa seeds, enhances survival and activity of antigen-specific CD8-positive T cells in vitro. J. Biomed. Sci., 2011, 68(3), 131-137.
[9]
Ballout, F.; Habli, Z.; Rahal, O.N.; Fatfat, M.; Muhtasib, H-G. Thymoquinone-based nanotechnology for cancer therapy: Promises and challenges. Drug Discov. Today, 2018, 23, 1089-1098.
[10]
Barkat, M.A.; Ahmad, J.; Khan, M.A.; Beg, S.; Ahmad, F.J. Insights into the targeting potential of thymoquinone for therapeutic intervention against triple-negative breast cancer. Curr. Drug Targets, 2018, 19(1), 70-80.
[11]
Rahmani, A.H. Anticancer action of thymoquinone. InMolecular and Therapeutic actions of Thymoquinone; Springer, 2018, pp. 19-39.
[12]
Alkharfy, K.M.; Ahmad, A.; Jan, B.L.; Raish, M. Thymoquinone reduces mortality and suppresses early acute inflammatory markers of sepsis in a mouse model. Biomed. Pharmacother., 2018, 98, 801-805.
[13]
Shaterzadeh-Yazdi, H.; Noorbakhsh, M.-F.; Hayati, F.; Samarghandian, S.; Farkhondeh, T. Immunomodulatory and anti-inflammatory effects of thymoquinone. Cardiovasc. Hematol. Disord.
Drug Targets (Formerly Current Drug Targets-
Cardiovascular & Hematological Disorders),, 2018. 18(1), 52-60.
[14]
Alemi, M.; Sabouni, F.; Sanjarian, F.; Haghbeen, K.; Ansari, S. Anti-inflammatory effect of seeds and callus of Nigella sativa L. extracts on mix glial cells with regard to their thymoquinone content. AAPS PharmSciTech, 2013, 14(1), 160-167.
[15]
Yi, T.; Cho, S-G.; Yi, Z.; Pang, X.; Rodriguez, M.; Wang, Y.; Sethi, G.; Aggarwal, B.B.; Liu, M. Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways. Mol. Cancer Ther., 2008, 7(7), 1789-1796.
[16]
Aggarwal, B.B.; Sethi, G.; Ahn, K.S.; Sandur, S.K.; Pandey, M.K.; Kunnumakkara, A.B.; Sung, B.; Ichikawa, H. Targeting signal‐transducer‐and‐activator‐of‐transcription‐3 for prevention and therapy of cancer. Ann. N. Y. Acad. Sci., 2006, 1091(1), 151-169.
[17]
Yue, P.; Turkson, J. Targeting STAT3 in cancer: How successful are we? Expert Opin. Investig. Drugs, 2009, 18(1), 45-56.
[18]
Bowman, T.; Garcia, R.; Turkson, J.; Jove, R. STATs in oncogenesis. Oncogene, 2000, 19(21), 2474.
[19]
Brierley, M.M.; Fish, E.N. Stats: Multifaceted regulators of transcription. J. Interferon Cytokine Res., 2005, 25(12), 733-744.
[20]
Li, F.; Rajendran, P.; Sethi, G. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway. Br. J. Pharmacol., 2010, 161(3), 541-554.
[21]
Jemal, A.; Bray, F.; Center, M.M.; Ferlay, J.; Ward, E.; Forman, D. Global cancer statistics. CA Cancer J. Clin., 2011, 61(2), 69-90.
[22]
Hanahan, D.; Weinberg, R.A. The hallmarks of cancer. Cell, 2000, 100(1), 57-70.
[23]
Evan, G.I.; Vousden, K.H. Proliferation, cell cycle and apoptosis in cancer. Nature, 2001, 411(6835), 342-348.
[24]
Goldfarb, M. The fibroblast growth factor family. Cell Growth Differ., 1990, 1, 439-445.
[25]
Ferrara, N. The role of vascular endothelial growth factor in pathological angiogenesis. Breast Cancer Res. Treat., 1995, 36(2), 127-137.
[26]
Folkman, J. Clinical applications of research on angiogenesis. N. Engl. J. Med., 1995, 333(26), 1757-1763.
[27]
Gasparini, G.; Harris, A.L. Clinical importance of the determination of tumor angiogenesis in breast carcinoma: Much more than a new prognostic tool. J. Clin. Oncol., 1995, 13(3), 765-782.
[28]
Stewart, M. Vascular endothelial Growth Factor (VEGF) biochemistry and development of inhibitory drugs. Curr. Drug Ther., 2012, 7(2), 80-89.
[29]
Rössler, J.; Lagodny, J. Blood and lymph vessels in embryonic tumors. Hematol. Ancol., 2005, 23(3‐4), 94-101.
[30]
Wang, Z. Dabrosin, C.; Yin, X.; Fuster, M.M.; Arreola, A.; Rathmell, W.K.; Generali, D.; Nagaraju, G.P.; El-Rayes, B.; Ribatti, D. InBroad targeting of angiogenesis for cancer prevention and therapy, Seminars in cancer biology; Elsevier, 2015, pp. S224-S243.
[31]
Voron, T.; Marcheteau, E.; Pernot, S.; Colussi, O.; Tartour, E.; Taieb, J.; Terme, M. Control of the immune response by pro-angiogenic factors. Front. Oncol., 2014, 4, 70.
[32]
Paramasivam, A.; Kalaimangai, M.; Sambantham, S.; Anandan, B.; Jayaraman, G. Anti-angiogenic activity of thymoquinone by the down-regulation of VEGF using zebrafish (Danio rerio) model. Biomed. Prev. Nutr., 2012, 2(3), 169-173.
[33]
Peng, L.; Liu, A.; Shen, Y.; Xu, H-Z.; Yang, S-Z.; Ying, X-Z.; Liao, W.; Liu, H-X.; Lin, Z-Q.; Chen, Q-Y. Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway. Oncol. Rep., 2013, 29(2), 571-578.
[34]
Suen, D-F.; Norris, K.L.; Youle, R.J. Mitochondrial dynamics and apoptosis. Genes Dev., 2008, 22(12), 1577-1590.
[35]
Rooney, S.; Ryan, M. Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. Anticancer Res., 2005, 25(3B), 2199-2204.
[36]
Alhosin, M.; Abusnina, A.; Achour, M.; Sharif, T.; Muller, C.; Peluso, J.; Chataigneau, T.; Lugnier, C.; Schini-Kerth, V.B.; Bronner, C. Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1. Biochem. Pharmacol., 2010, 79(9), 1251-1260.
[37]
Hatiboglu, M.A.; Kocyigit, A.; Guler, E.M.; Akdur, K.; Nalli, A.; Karatas, E.; Tuzgen, S. Thymoquinone induces apoptosis in B16-F10 melanoma cell through inhibition of p-STAT3 and inhibits tumor growth in a murine intracerebral melanoma model. World Neurosurg., 2018, 114, e182-e190.
[38]
Halagali-Muhtasib, M-A.; Boltze, C.; Al-Hmaira, J.; Hartig, R.; Roessner, A.; Schneider-Stock, R. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int. J. Oncol., 2004, 25, 857-866.
[39]
Paramasivam, A.; Raghunandhakumar, S.; Sambantham, S.; Anandan, B.; Rajiv, R.; Priyadharsini, J.V.; Jayaraman, G. In vitro anticancer and anti-angiogenic effects of thymoquinone in mouse neuroblastoma cells (Neuro-2a). Biomed. Prev. Nutr., 2012, 2(4), 283-286.
[40]
Fidler, I.J. The pathogenesis of cancer metastasis: The ‘seed and soil’ hypothesis revisited. Nat. Rev. Cancer, 2003, 3(6), 453-458.
[41]
Shaterzadeh-Yazdi, H.; Noorbakhsh, M-F.; Samarghandian, S.; Farkhondeh, T. An overview on renoprotective effects of thymoquinone. Kidney Dis., 2018, 4, 74-82.
[42]
Diwaker, A.; Gunjan, J. Plant-based anticancer molecules: A chemical and biological profile of some important leads. Int. J. Adv. Res. Pharm. Bio Sci., 2012, 1(2), 16-25.
[43]
Srivastava, V.; Negi, A.S.; Kumar, J.; Gupta, M.; Khanuja, S.P. Plant-based anticancer molecules: A chemical and biological profile of some important leads. Bioorg. Med. Chem., 2005, 13(21), 5892-5908.
[44]
Younus, H.; Younus, H. Sawhney, molecular and therapeutic:
Actions of thymoquinone. 1st. ed, Springer: 2018.
[45]
Ozturk, S.A.; Alp, E.; Saglam, A.S.Y.; Konac, E.; Menevse, E.S. The effects of thymoquinone and genistein treatment on telomerase activity, apoptosis, angiogenesis, and survival in thyroid cancer cell lines. J. Cancer Res. Ther., 2018, 14(2), 328-334.
[46]
Asfour, W.; Almadi, S.; Haffar, L. Thymoquinone suppresses cellular proliferation, inhibits VEGF production and obstructs tumor progression and invasion in the rat model of DMH-induced colon carcinogenesis. Pharmacol. Pharm., 2013, 4(01), 7.