Login Register Cart 0
Generic placeholder image

Current Neurovascular Research

Editor-in-Chief

ISSN (Print): 1567-2026
ISSN (Online): 1875-5739

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Glucose Levels and Outcome After Primary Intraventricular Hemorrhage

Author(s): Rui Guo, Ruiqi Chen, Chao You, Lu Ma, Hao Li and Yuan Fang*

Volume 16, Issue 1, 2019

Page: [40 - 46] Pages: 7

DOI: 10.2174/1567202616666190131164108

Price: $65

Abstract

Background and Purpose: Hyperglycemia is reported to be associated with poor outcome in patients with spontaneous Intracerebral Hemorrhage (ICH), but the association between blood glucose level and outcomes in Primary Intraventricular Hemorrhage (PIVH) remains unclear. We sought to identify the parameters associated with admission hyperglycemia and analyze the impact of hyperglycemia on clinical outcome in patients with PIVH.

Methods: Patients admitted to Department of Neurosurgery, West China Hospital with PIVH between 2010 and 2016 were retrospectively included in our study. Clinical, radiographic, and laboratory data were collected. Univariate and multivariate logistic regression analyses were used to identify independent predictors of poor outcomes.

Results: One hundred and seventy patients were included in the analysis. Mean admission blood glucose level was 7.78±2.73 mmol/L and 10 patients (5.9%) had a history of diabetes mellitus. History of diabetes mellitus (P = 0.01; Odds Ratio [OR], 9.10; 95% Confidence Interval [CI], 1.64 to 50.54) was independent predictor of admission critical hyperglycemia defined at 8.17 mmol/L. Patients with admission critical hyperglycemia poorer outcome at discharge (P < 0.001) and 90 days (P < 0.001). After adjustment, admission blood glucose was significantly associated with discharge (P = 0.01; OR, 1.30; 95% CI, 1.06 to 1.59) and 90-day poor outcomes (P = 0.03; OR, 1.27; 95% CI, 1.03 to 1.58), as well as mortality at 90 days (P = 0.005; OR, 1.41; 95% CI, 1.11 to 1.78). In addition, admission critical hyperglycemia showed significantly increased the incidence rate of pneumonia in PIVH (P = 0.02; OR, 6.04; 95% CI 1.27 to 28.80) even after adjusting for the confounders.

Conclusion: Admission blood glucose after PIVH is associated with discharge and 90-day poor outcomes, as well as mortality at 90 days. Admission hyperglycemia significantly increases the incidence rate of pneumonia in PIVH.

Keywords: Primary intraventricular hemorrhage, glucose, risk factors and outcome, hyperglycemia, cerebral injuries, intraventricular hemorrhage.

« Previous Next »
[1]
Fogelholm R, Murros K, Rissanen A, Avikainen S. Admission blood glucose and short term survival in primary intracerebral haemorrhage: A population based study. J Neurol Neurosurg Psychiatry 2005; 76(3): 349-53.
[2]
Bejot Y, Aboa-Eboule C, Hervieu M, et al. The deleterious effect of admission hyperglycemia on survival and functional outcome in patients with intracerebral hemorrhage. Stroke 2012; 43(1): 243-5.
[3]
Kim Y, Han MH, Kim CH, Kim JM, Cheong JH, Ryu JI. Increased short-term mortality in patients with spontaneous intracerebral hemorrhage and its association with admission glucose levels and leukocytosis. World Neurosurg 2017; 98: 503-11.
[4]
McIntosh TK, Yu T, Gennarelli TA. Alterations in regional brain catecholamine concentrations after experimental brain injury in the rat. J Neurochem 1994; 63(4): 1426-33.
[5]
Tomlinson DR, Gardiner NJ. Glucose neurotoxicity. Nat Rev Neurosci 2008; 9(1): 36-45.
[6]
Stead LG, Jain A, Bellolio MF, et al. Emergency department hyperglycemia as a predictor of early mortality and worse functional outcome after intracerebral hemorrhage. Neurocrit Care 2010; 13(1): 67-74.
[7]
Lee SH, Kim BJ, Bae HJ, et al. Effects of glucose level on early and long-term mortality after intracerebral haemorrhage: The Acute Brain Bleeding Analysis Study. Diabetologia 2010; 53(3): 429-34.
[8]
Appelboom G, Piazza MA, Hwang BY, et al. Severity of intraventricular extension correlates with level of admission glucose after intracerebral hemorrhage. Stroke 2011; 42(7): 1883-8.
[9]
Saxena A, Anderson CS, Wang X, et al. Prognostic significance of hyperglycemia in acute intracerebral hemorrhage: The INTERACT2 study. Stroke 2016; 47(3): 682-8.
[10]
Darby DG, Donnan GA, Saling MA, Walsh KW, Bladin PF. Primary intraventricular hemorrhage: Clinical and neuropsychological findings in a prospective stroke series. Neurology 1988; 38(1): 68-75.
[11]
Gates PC, Barnett HJ, Vinters HV, Simonsen RL, Siu K. Primary intraventricular hemorrhage in adults. Stroke 1986; 17(5): 872-7.
[12]
Angelopoulos M, Gupta SR, Azat Kia B. Primary intraventricular hemorrhage in adults: Clinical features, risk factors, and outcome. Surg Neurol 1995; 44(5): 433-6. discussion 437.
[13]
Tembl J, Lago A, Baquero M, Blasco R. Primary intraventricular hemorrhage: An analysis of eight cases. Rev Neurol 1997; 25(138): 215-8.
[14]
Chang DS, Lin CL, Howng SL. Primary intraventricular hemorrhage in adult--an analysis of 24 cases. Kaohsiung J Med Sci 1998; 14(10): 633-8.
[15]
Marti-Fabregas J, Piles S, Guardia E, Marti-Vilalta JL. Spontaneous primary intraventricular hemorrhage: Clinical data, etiology and outcome. J Neurol 1999; 246(4): 287-91.
[16]
Flint AC, Roebken A, Singh V. Primary intraventricular hemorrhage: Yield of diagnostic angiography and clinical outcome. Neurocrit Care 2008; 8(3): 330-6.
[17]
Giray S, Sen O, Sarica FB, et al. Spontaneous primary intraventricular hemorrhage in adults: Clinical data, etiology and outcome. Turk Neurosurg 2009; 19(4): 338-44.
[18]
Srivastava T, Sannegowda RB, Satija V, Jain RS, Tejwani S, Mathur T. Primary intraventricular hemorrhage: Clinical features, risk factors, etiology, and yield of diagnostic cerebral angiography. Neurol India 2014; 62(2): 144-8.
[19]
Lee SH, Park KJ, Park DH, Kang SH, Park JY, Chung YG. Factors associated with clinical outcomes in patients with primary intraventricular hemorrhage. Med Sci Monit 2017; 23: 1401-12.
[20]
Weinstein R, Ess K, Sirdar B, Song S, Cutting S. Primary intraventricular hemorrhage: Clinical characteristics and outcomes. J Stroke Cerebrovasc Dis 2017; 26(5): 995-9.
[21]
Graeb DA, Robertson WD, Lapointe JS, Nugent RA, Harrison PB. Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis. Radiology 1982; 143(1): 91-6.
[22]
Oh TK, Song IA, Lee JH, et al. Effect of preadmission glucocorticoid therapy on 30-day mortality in critically ill patients: A retrospective study of a mixed ICU population in a tertiary hospital. Ann Intensive Care 2019; 9(1): 8.
[23]
Gray CS, Hildreth AJ, Sandercock PA, et al. Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST-UK). Lancet Neurol 2007; 6(5): 397-406.
[24]
Bellolio MF, Gilmore RM, Ganti L. Insulin for glycaemic control in acute ischaemic stroke. Cochrane Database Syst Rev 2014; 2014(1): Cd005346.
[25]
Sullivan GM, Canfield SM, Lederman S, Xiao E, Ferin M, Wardlaw SL. Intracerebroventricular injection of interleukin-1 suppresses peripheral lymphocyte function in the primate. Neuroimmunomodulation 1997; 4(1): 12-8.
[26]
Passero S, Ciacci G, Ulivelli M. The influence of diabetes and hyperglycemia on clinical course after intracerebral hemorrhage. Neurology 2003; 61(10): 1351-6.
[27]
Kimura K, Iguchi Y, Inoue T, et al. Hyperglycemia independently increases the risk of early death in acute spontaneous intracerebral hemorrhage. J Neurol Sci 2007; 255(1-2): 90-4.
[28]
Godoy DA, Pinero GR, Svampa S, Papa F, Di Napoli M. Hyperglycemia and short-term outcome in patients with spontaneous intracerebral hemorrhage. Neurocrit Care 2008; 9(2): 217-29.
[29]
Pampfer S, Cordi S, Dutrieux C, Vanderheyden I, Marchand C, De Hertogh R. Interleukin 1beta mediates the effect of high D-glucose on the secretion of TNF-alpha by mouse uterine epithelial cells. Cytokine 1999; 11(7): 500-9.
[30]
Chiu CD, Chen TY, Chin LT, et al. Investigation of the effect of hyperglycemia on intracerebral hemorrhage by proteomic approaches. Proteomics 2012; 12(1): 113-23.
[31]
Echouffo-Tcheugui JB, Zhao S, Brock G, Matsouaka RA, Kline D, Joseph JJ. Visit-to-visit glycemic variability and risks of cardiovascular events and all-cause mortality: The ALLHAT study. Diabetes Care 2019; 1: dc181430.

Rights & Permissions Print Cite
Article Metrics
68
3
1
1
© 2024 Bentham Science Publishers | Privacy Policy