摘要
弥漫性大B细胞淋巴瘤（DLBCL）是成人中最常见的B型非霍奇金淋巴瘤。 引入利妥昔单抗治疗DLBCL后，当前的一线治疗是R-CHOP方案。 该方案极大地改善了患者的预后，但是，复发或难治性病例屡见不鲜，主要是由于对利妥昔单抗的耐药性。 尽管已经进行了大量实验来研究利妥昔单抗的耐药性，但是其exac机制和解决方案仍不清楚。 这篇综述主要探讨了对利妥昔单抗耐药的可能机制和目前对DLBCL利妥昔单抗耐药的新有效治疗方法。
关键词: 弥漫性大B细胞淋巴瘤，CD20，利妥昔单抗耐药，生物标志物，非霍奇金淋巴瘤，预后。
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