Abstract
Background: This paper describes the synthesis of four novel fused heterocycles from the condensation reaction of chalcone derivatives with amino derivatives. Herein we describe the synthesis of twelve compounds by both conventional and microwave method. The synthesized compounds are excellent in utilizing microwave irradiation rather than conventional heating.
Methods: Synthesis of substituted heterocycles was carried out under microwave radiation and conventional heating.
Results: The comparison study between the microwave and conventional synthesis proved that microwave synthesis is the best and it is a current lead in Organic synthesis. In anti-convulsant evaluation, compounds IIa, IIIa, IVa produced a significant activity by the abolition of extensor phase. In the anti-inflammatory evaluation, compounds IIb and IIc produced a significant activity due to the presence of the pyrazoline nucleus.
Conclusion: In an experimental procedure, 4- acetamido phenol was reacted with an aromatic aldehyde to give chalcones. These chalcones on cyclization and condensation with hydrazine hydrate, thiourea, guanidine nitrate gave pyrazolines, aminopyrimidines, and pyrimidine thiones, respectively The compounds were subjected to anti-convulsant and anti-inflammatory evaluation.
Keywords: Chalcones, MORE, microwave irradiation, pyrimidine thiones, anticonvulsant, anti-inflammatory.
Graphical Abstract
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