Review Article

钒和氧化应激标记物-体内模型:综述

卷 26, 期 29, 2019

页: [5456 - 5500] 页: 45

弟呕挨: 10.2174/0929867326666190108112255

价格: $65

摘要

这篇综述文章旨在总结钒(V)对体内氧化应激(OS)标记的影响的当前知识状态。它显示了我们的研究结果以及其他研究人员对不同V化合物对所选活性氧(ROS)/自由基(FRs),脂质过氧化标记(LPO)和酶促标记物水平的影响的研究结果和非酶类抗氧化剂。它还介绍了ROS /过氧化物对V调节的抗氧化酶活性的影响,并说明了由这种金属和活性氧代谢物引起的ROS失活的机理。它还集中于V与抗氧化系统的一些非酶化合物的相互作用机理。此外,我们回顾了氧衍生的FRs和非自由基氧衍生物(其中涉及V)的生成途径,以及FR介导的LPO(由这种金属诱导)的后果,以及其负面/正面影响。 LPO产品。还简要介绍了一些抗氧化剂酶和低分子量抗氧化剂的定位和功能,它们能够与V形成络合物,并在该元素的代谢中起关键作用。该报告还显示了时间表上的OS历史背景和OS标记(由接受V处理的动物确定),收集了有关V与具有抗氧化潜力的元素之一相互作用的数据,并强调了进行相互作用研究的必要性和必要性。在V和抗氧化剂元素之间。

关键词: 钒,氧化应激标志物,动物研究,镁,相互作用,活性氧(ROS),脂质过氧化(LPO),抗氧化剂。

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