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Review Article

基于基因的治疗角膜疾病治疗工具

卷 19, 期 1, 2019

页: [7 - 19] 页: 13

弟呕挨: 10.2174/1566523219666181213120634

价格: $65

摘要

背景：作为主要致盲性眼病之一，新生血管形成导致角膜失明，破坏了角膜无血管的血管生成特性。在新血管形成后，炎性细胞浸润到角膜中以加强角膜损伤。几十年来一直在研究如何维持角膜血管生成特权来治疗角膜疾病。 方法：局部施用病毒和非病毒介导的抗血管生成因子原位减少血管生成蛋白表达，对基因递送有限或没有脱靶效应。最近，已经研究了间充质干细胞（MSCs）来治疗角膜疾病。一旦MSC被操纵以表达某些感兴趣的基因，它们可以在移植后获得优异的治疗功效。 讨论：在文中，我们首先介绍角膜病在新生血管和炎症方面的病理学发展。我们总结了MSCs如何成为治疗角膜受损的细胞疗法的理想候选者，专注于细胞生物学，性质和特征。我们在控制靶基因表达，安全性和有效性方面提供了动物基因治疗和临床前研究的最新综述。基因转移载体有效诱导候选蛋白质表达。通过载体递送，MSC通过表达目的蛋白质而具有某些特征，这有利于MSC介导的治疗干预以治疗角膜疾病。 结论：作为本综述的核心，我们讨论了如何将MSCs设计成载体系统，以提高注射后的治疗效率。

关键词: 基因治疗，间充质干细胞，角膜病，炎症，VEGF，αSMA。

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