Login Register Cart 0
Generic placeholder image

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Anti-inflammatory and Antioxidant Activities of the Extracts from Leaves and Stems of Polygonum odoratum Lour

Author(s): Nittaya Chansiw, Kamonnaree Chotinantakul and Somdet Srichairatanakool*

Volume 18, Issue 1, 2019

Page: [45 - 54] Pages: 10

DOI: 10.2174/1871523017666181109144548

Abstract

Background: Polygonum odoratum is an indigenous vegetable that has been used as a favoring agent and also used as a Thai traditional medicine to treat flatulence.

Objective: To analyze active ingredients, total phenolic and total flavonoid contents, antiinflammatory and antioxidant activities from leaf and stem extracts of P. odoratum.

Methods: Leaves and stems were dried and extracted by using methanol, dichloromethane and water for obtaining Methanolic Leaf Extract (MLE), Methanolic Stem Extract (MTE), Dichloromethane Leaf Extract (DLE), Dichloromethane Stem Extract (DTE), Water Leaf Extract (WLE) and Water Stem Extract (WTE). The extracts were quantified for total phenolic and total flavonoid contents by spectrophotometry and active compounds were analyzed by using GC-MS. Antioxidant activity was determined by ABTS and DPPH radicals scavenging assays. Anti-inflammatory activity was tested by the inhibition of nitric oxide production in RAW 264.7 macrophage cells induced by lipopolysaccharide.

Results: The DLE exhibited the most potent anti-inflammatory effect by inhibiting nitric oxide production in a concentration-dependent manner (IC50 = 53.75±0.72 µg/mL). MLE exhibited strong antioxidant activity and contained the highest concentration of phenolic compounds (52.59±0.58 mg gallic acid equivalent/g extract) and flavonoid (19.97+0.11 mg quercetin equivalent/g extract). E-15-Heptadecenal and 3, 7, 11, 15-tetramethyl-2- hexadecen-1-ol were found predominantly in the methanol extracts.

Conclusion: The leaf extract of P. odoratum showed potent anti-inflammatory and antioxidant activities, mediated by DLE and MLE, respectively.

Keywords: Anti-inflammation, antioxidant, macrophage, nitric oxide, Polygonum odoratum, phenolic compounds.

« Previous Next »
Graphical Abstract

[1]
White, M. Mediators of inflammation and the inflammatory process. J. Allergy Clin. Immunol., 1999, 103(3 Pt 2), S378-S381.
[2]
Nagy, G.; Clark, J.M.; Buzas, E.I.; Gorman, C.L.; Cope, A.P. Nitric oxide, chronic inflammation and autoimmunity. Immunol. Lett., 2007, 111(1), 1-5.
[3]
Pawelec, G.; Goldeck, D.; Derhovanessian, E. Inflammation, ageing and chronic disease. Curr. Opin. Immunol., 2014, 29, 23-28.
[4]
Tokmachev, R.E.; Budnevsky, A.V.; Kravchenko, A.Y. The role of inflammation in the pathogenesis of chronic heart failure. Ter. Arkh., 2016, 88(9), 106-110.
[5]
Okada, Y. Pathoetiology of chronic rheumatoid arthritis--from inflammation to bone destruction. 1) From the viewpoint of pathology. Nippon Naika Gakkai Zasshi, 2000, 89(10), 2072-2080.
[6]
O’Byrne, K.J.; Dalgleish, A.G. Chronic immune activation and inflammation as the cause of malignancy. Br. J. Cancer, 2001, 85(4), 473-483.
[7]
Lei, Y.; Wang, K.; Deng, L.; Chen, Y.; Nice, E.C.; Huang, C. Redox regulation of inflammation: Old elements, a new story. Med. Res. Rev., 2014, 35(2), 306-340.
[8]
Thanan, R.; Oikawa, S.; Hiraku, Y.; Ohnishi, S.; Ma, N.; Pinlaor, S.; Yongvanit, P.; Kawanishi, S.; Murata, M. Oxidative stress and its significant roles in neurodegenerative diseases and cancer. Int. J. Mol. Sci., 2014, 16(1), 193-217.
[9]
Anand, D.A.V.; Arulmoli, R.; Parasuraman, S. Overviews of biological importance of quercetin: A bioactive flavonoid. Pharmacogn. Rev., 2017, 10(20), 84-89.
[10]
Burns, J.; Gardner, P.T.; Matthews, D.; Duthie, G.G.; Lean, M.E.; Crozier, A. Extraction of phenolics and changes in antioxidant activity of red wines during vinification. J. Agric. Food Chem., 2001, 49(12), 5797-5808.
[11]
Starkenmann, C.; Luca, L.; Niclass, Y.; Praz, E.; Roguet, D. Comparison of volatile constituents of Persicaria odorata (Lour.) Sojak (Polygonum odoratum Lour.) and Persicaria hydropiper L. Spach (Polygonum hydropiper L.). J. Agric. Food Chem., 2006, 54(8), 3067-3071.
[12]
Somananda, K.; Ahongshangbam, G.; Chattopadhyay, S. Bioactive compounds and antioxidant activity of Polygonum odoratum Lour. Int. J. Bas. Appl. Biol., 2014, 2(1), 94-97.
[13]
Legault, J.; Perron, T.; Mshvildadze, V.; Girard-Lalancette, K.; Perron, S.; Laprise, C.; Sirois, P.; Pichette, A. Antioxidant and anti-inflammatory activities of quercetin 7-O-beta-D-glucopyranoside from the leaves of Brasenia schreberi. J. Med. Food, 2011, 14(10), 1127-1134.
[14]
Pieroni, L.G.; de Rezende, F.M.; Ximenes, V.F.; Dokkedal, A.L. Antioxidant activity and total phenols from the methanolic extract of Miconia albicans (Sw.) Triana leaves. Molecules, 2011, 16(11), 9439-9450.
[15]
Curcic, M.G.; Stankovic, M.S.; Radojevic, I.D.; Stefanovic, O.D.; Comic, L.R.; Topuzovic, M.D.; Djacic, D.S.; Markovic, S.D. Biological effects, total phenolic content and flavonoid concentrations of fragrant yellow onion (Allium flavum L.). Med. Chem., 2012, 8(1), 46-51.
[16]
Eseyin, O.A.; Daniel, A.; Paul, T.S.; Attih, E.; Emmanuel, E.; Ekarika, J.; Munavvar, Z.A.S.; Ashfaq, A.; Afzal, S.; Ukeme, A. Phytochemical analysis and antioxidant activity of the seed of Telfairia occidentalis Hook (Cucurbitaceae). Nat. Prod. Res., 2017, 32(4), 444-447.
[17]
Vitalini, S.; Madeo, M.; Tava, A.; Iriti, M.; Vallone, L.; Avato, P.; Cocuzza, C.E.; Simonetti, P.; Argentieri, M.P. Chemical profile, antioxidant and antibacterial activities of Achillea moschata wulfen, an endemic species from the alps. Molecules, 2016, 21(7), E830.
[18]
Cai, Y.; Hu, X.; Huang, M.; Sun, F.; Yang, B.; He, J.; Wang, X.; Xia, P.; Chen, J. Characterization of the antibacterial activity and the chemical components of the volatile oil of the leaves of Rubus parvifolius L. Molecules, 2012, 17(7), 7758-7768.
[19]
Ferrari, M.; Fornasiero, M.C.; Isetta, A.M. MTT colorimetric assay for testing macrophage cytotoxic activity in vitro. J. Immunol. Methods, 1990, 131(2), 165-172.
[20]
Dong, L.; Yin, L.; Zhang, Y.; Fu, X.; Lu, J. Anti-inflammatory effects of ononin on lipopolysaccharide-stimulated RAW 264.7 cells. Mol. Immunol., 2017, 83, 46-51.
[21]
Pandey, K.B.; Rizvi, S.I. Plant polyphenols as dietary antioxidants in human health and disease. Oxid. Med. Cell. Longev., 2009, 2(5), 270-278.
[22]
Fujita, K.; Chavasiri, W.; Kubo, I. Anti-salmonella activity of volatile compounds of Vietnam coriander. Phytother. Res., 2015, 29(7), 1081-1087.
[23]
Sajid, M.; Khan, M.R.; Shah, S.A.; Majid, M.; Ismail, H.; Maryam, S.; Batool, R.; Younis, T. Investigations on anti-inflammatory and analgesic activities of Alnus nitida Spach (Endl). stem bark in Sprague Dawley rats. J. Ethnopharmacol., 2017, 198, 407-416.
[24]
Gutierrez, N.Z.J.; Jimenez-Aparicio, A.R.; Herrera-Ruiz, M.L.; Jimenez-Ferrer, E. Immunomodulatory effect of Agave tequilana evaluated on an autoimmunity like-SLE model induced in Balb/c mice with pristane. Molecules, 2017, 22(6), E848.
[25]
Angelovich, T.A.; Hearps, A.C.; Jaworowski, A. Inflammation-induced foam cell formation in chronic inflammatory disease. Immunol. Cell Biol., 2015, 93(8), 683-693.
[26]
Laroux, F.S.; Lefer, D.J.; Kawachi, S.; Scalia, R.; Cockrell, A.S.; Gray, L.; Van der Heyde, H.; Hoffman, J.M.; Grisham, M.B. Role of nitric oxide in the regulation of acute and chronic inflammation. Antioxid. Redox Signal., 2000, 2(3), 391-396.

Rights & Permissions Print Cite
Article Metrics
81
4
© 2024 Bentham Science Publishers | Privacy Policy