Generic placeholder image

Current Molecular Medicine

Editor-in-Chief

ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Critical Role for IL-15 in Innate Immunity

Author(s): Toshiaki Ohteki

Volume 2, Issue 4, 2002

Page: [371 - 380] Pages: 10

DOI: 10.2174/1566524023362519

Price: $65

Abstract

Although some functional activities of interleukin (IL)-15 on NK and T cells overlap with those of IL-2, recent findings obtained from gene-targeted mice deficient in components of IL-2 / IL-15 system demonstrate distinct roles of IL-15 for the activation of innate immune system. IL-15 is a pivotal cytokine for the development and survival of NK cells, NKT cells, TCRγδ+ intestinal intraepithelial lymphocytes (iIEL), and for the functional maturation of dendritic cells and macrophages. IL-15 is also important for memory T cell maintenance in vivo. In this review, I summarize recent progress of studies in the IL-15 / IL-15R system.

Keywords: il-15, il-2, innate immunity, iel, il-15/il-15r


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy