Review Article

精油:合成抗菌药物的迫切替代品,以克服抗菌药物耐药性

卷 20, 期 6, 2019

页: [605 - 624] 页: 20

弟呕挨: 10.2174/1389450119666181031122917

价格: $65

摘要

抗菌药物耐药性(AMR)是世界上一个对我们的社会产生重大影响的新兴问题。 AMR使常规药物对微生物和疾病无效,无法治愈。与合成药物相比,植物衍生药物被认为是安全的替代药物。由于其易得性,低成本和可忽略的副作用,活性成分和这些天然药物的混合物已经使用了几个世纪。精油(EOs)是芳香植物产生的次级代谢产物,可以保护它们免受微生物的侵害。然而,这些环境影响评估及其成员已显示出对抗耐药病原体的良好战斗潜力。与抗生素相比,这些油已被证明是非常有效的抗微生物剂。此外,合成药物与EO或其组分的组合可改善其功效。因此,可以建立EO作为合成抗菌剂的替代品,以根除坚韧形式的传染性微生物。 EO可以与多个目标位点相互作用,如细胞质膜的破坏或蛋白质合成和外排泵的抑制等。本综述的目的是提供有关不同植物获得的EOs抗菌活性的信息,它们与合成抗菌药物的组合。此外,还报道了几种EOs及其成分的抗菌活性机制。

关键词: 抗菌素,精油,机制,与抗生素的组合,EOs及其成分的组合,协同作用。

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图形摘要

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