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General Review Article

脂质作为肽疫苗的先天免疫激活物

卷 27, 期 17, 2020

页: [2887 - 2901] 页: 15

弟呕挨: 10.2174/0929867325666181026100849

价格: $65

摘要

背景: 先天免疫系统在病原检测和疫苗识别中发挥着重要作用，主要通过模式识别受体(pattern recognition receptor, PRRs)识别病原成分(危险信号)。典型的细菌成分之一是与肽、蛋白质和糖类结合的脂质。脂类化合物很容易被免疫系统识别，因此是肽类疫苗的理想载体。因此，细菌或合成的与抗原混合或结合的脂质显示出佐剂性质。与传统佐剂相比，这些系统具有毒性低、对粘膜和全身免疫反应有良好的刺激作用等优点。 方法: 本文选取了有关脂质在刺激免疫反应中的作用的最新文献进行综述。绝大多数被评论的论文都是在过去十年中发表的。更古老但重要的发现也被引用。 结果: 本文综述了脂肽疫苗体系的研究进展，包括棕榈酸、细菌脂肽、糖脂和脂核肽的应用及其给药途径。讨论了脂质体作为含脂肽的传递系统的使用。本文还简要介绍了免疫系统与疫苗学的关系，并讨论了疫苗的传递途径。 结论: 脂质及其偶联物是开发针对不同免疫途径的安全和高效疫苗的理想先导物。

关键词: 肽链型疫苗

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