摘要
肺腺癌是全世界癌症患者死亡的主要原因之一,慢性阻塞性肺病(COPD)在死亡统计中也很高。此外,慢性阻塞性肺疾病(COPD)患者发展为原发性肺癌的风险很高。预防、风险评估和非侵入性诊断对降低COPD和肺癌死亡率至关重要。因此,需要更好、更准确的分子诊断标志物(biomarkers)对这些肺部疾病进行早期鉴别诊断,以帮助临床医生做出更好的治疗决定。这篇综述集中在最近发现的腺癌和COPD在蛋白质组和糖蛋白水平上的生物标志物。第一部分是对蛋白质标记的总结,第二部分是对多糖标记的研究。它们用于区分慢性炎症(COPD)和恶性(腺癌)疾病的详细讨论。
关键词: 肺癌,肺腺癌,COPD,分子标记,蛋白质组学,糖组学。
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