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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Research Article

Reuse of Biopsy Forceps may be Associated with Risk of Transmission of HCV in Egyptian Patients Undergoing Gastrointestinal Endoscopy.

Author(s): Taher El-Demerdash, Mohamed Yousef , Sherief Abd-Elsalam*, Amal Helmy, Abdelrahman Kobtan and Asem A. Elfert

Volume 19, Issue 3, 2019

Page: [279 - 283] Pages: 5

DOI: 10.2174/1871526518666181015164002

Price: $65

Abstract

Background and Aims: Hepatitis viruses are not transmitted via gastrointestinal endoscopy except if there are any mistakes in sterilization and disinfection of the endoscope that disrupt the infection control measures. So we aimed to measure the risk of transmitting HCV by GI endoscopy at department of Tropical Medicine and infectious Diseases, in a major University hospital in Egypt.

Methods: Our study was conducted on four hundred patients with exclusion of those with HCV, HBV, and/or HIV positive antibodies. An ethical committee approval and a given consent were taken prior to enrollment on the study. Our patients are grouped into the following; 100 patients undergoing upper GI endoscopy without biopsy as group I; 100 patients undergoing upper GI endoscopy with biopsy as group II; 100 patients undergoing lower GI endoscopy without biopsy as group III and 100 patients undergoing lower GI endoscopy with biopsy as group IV. HCV antibodies were done 3 months after endoscopy with exclusion of other risks of HCV infection by a detailed questionnaire.

Results: Only one case was reported positive after 3 months of procedure; it was after colonoscopy with biopsy using reusable forceps.

Conclusions: Strict infection control measures of the GI endoscopes despite being effective in preventing HCV transmission, the reuse of disinfected biopsy forceps may be associated with a risk of transmission. So, we recommend using disposable forceps for every patient to omit the risk of HCV transmission during endoscopy.

Keywords: HCV transmission, endoscopy, biopsy forceps, Egypt, patients, risk.

[1]
Abd-Elsalam, S.; Sharaf-Eldin, M.; Soliman, S.; Elfert, A.; Badawi, R.; Ahmad, Y.K. Efficacy and safety of sofosbuvir plus ribavirin for treatment of cirrhotic patients with genotype 4 hepatitis C virus in real-life clinical practice. Arch. Virol. Epub ahead of print, 2017.
[http://dx.doi.org/10.1007/s00705-017-3573-0] [PMID: 28983675]
[2]
Ahmed, O.A.; Kaisar, H.H.; Hawash, N.; Samir, H.; Shabana, S.S.T.; Hassan A Fouad, M.; Rizk, F.; Abd-Elsalam, S. Efficacy of Sofosbuvir Plus Ribavirin with or Without Peginterferon- Alfa in Treatment of a Cohort of Egyptian Patients with Hepatitis C Virus Infection. Infect. Disord. Drug Targets, 2017, 17(2), 95-100.
[http://dx.doi.org/10.2174/1871526517666170417143216] [PMID: 28413993]
[3]
Allen, J.I.; Allen, M.O.; Olson, M.M.; Gerding, D.N.; Shanholtzer, C.J.; Meier, P.B.; Vennes, J.A.; Silvis, S.E. Pseudomonas infection of the biliary system resulting from use of a contaminated endoscope. Gastroenterology, 1987, 92(3), 759-763.
[http://dx.doi.org/10.1016/0016-5085(87)90029-1] [PMID: 3817396]
[4]
Bronowicki, J.P.; Venard, V.; Botté, C.; Monhoven, N.; Gastin, I.; Choné, L.; Hudziak, H.; Rihn, B.; Delanoë, C.; LeFaou, A.; Bigard, M.A.; Gaucher, P. Patient-to-patient transmission of hepatitis C virus during colonoscopy. N. Engl. J. Med., 1997, 337(4), 237-240.
[http://dx.doi.org/10.1056/NEJM199707243370404] [PMID: 9227929]
[5]
Ciancio, A.; Manzini, P.; Castagno, F.; D’Antico, S.; Reynaudo, P.; Coucourde, L.; Ciccone, G.; Del Piano, M.; Ballarè, M.; Peyre, S.; Rizzi, R.; Barletti, C.; Bruno, M.; Caronna, S.; Carucci, P. Venon, Wde.B.; De Angelis, C.; Morgando, A.; Musso, A.; Repici, A.; Rizzetto, M.; Saracco, G. Digestive endoscopy is not a major risk factor for transmitting hepatitis C virus. Ann. Intern. Med., 2005, 142(11), 903-909.
[http://dx.doi.org/10.7326/0003-4819-142-11-200506070-00008] [PMID: 15941697]
[6]
El-Demerdash, T; Yousef, M AbdElsalam, S; AbdElsalam, S. Reuse of biopsy forceps may be associated with risk of transmission of HCV in Egyptian patients undergoing gastrointestinal endoscopy. Hepat Int. (Abstract in Apasl-2017 conference), 2017, 11(1), s1067.
[7]
Elwan, N.; Elfert, A.; Abd-Elsalam, S.; Alska, A.; Kobtan, A.; Yousef, M. Study of hepatic steatosis index in patients with chronic hcv infection. Int. J. Curr. Microbiol. Appl. Sci., 2016, 5(5), 266-274.
[http://dx.doi.org/10.20546/ijcmas.2016.505.029]
[8]
Frank, C.; Mohamed, M.K.; Strickland, G.T.; Lavanchy, D.; Arthur, R.R.; Magder, L.S.; El Khoby, T.; Abdel-Wahab, Y.; Aly Ohn, E.S.; Anwar, W.; Sallam, I. The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt. Lancet, 2000, 355(9207), 887-891.
[http://dx.doi.org/10.1016/S0140-6736(99)06527-7] [PMID: 10752705]
[9]
González-Candelas, F.; Guiral, S.; Carbó, R.; Valero, A.; Vanaclocha, H.; González, F.; Bracho, M.A. Patient-to-patient transmission of hepatitis C virus (HCV) during colonoscopy diagnosis. Virol. J., 2010, 7, 217-226.
[http://dx.doi.org/10.1186/1743-422X-7-217] [PMID: 20825635]
[10]
Gutelius, B.; Perz, J.F.; Parker, M.M.; Hallack, R.; Stricof, R.; Clement, E.J.; Lin, Y.; Xia, G.L.; Punsalang, A.; Eramo, A.; Layton, M.; Balter, S. Multiple clusters of hepatitis virus infections associated with anesthesia for outpatient endoscopy procedures. Gastroenterology, 2010, 139(1), 163-170.
[http://dx.doi.org/10.1053/j.gastro.2010.03.053] [PMID: 20353790]
[11]
Habib, M.; Mohamed, M.K.; Abdel-Aziz, F.; Magder, L.S.; Abdel-Hamid, M.; Gamil, F.; Madkour, S.; Mikhail, N.N.; Anwar, W.; Strickland, G.T.; Fix, A.D.; Sallam, I. Hepatitis C virus infection in a community in the Nile Delta: risk factors for seropositivity. Hepatology, 2001, 33(1), 248-253.
[http://dx.doi.org/10.1053/jhep.2001.20797] [PMID: 11124843]
[12]
Medhat, A.; Shehata, M.; Magder, L.S.; Mikhail, N.; Abdel-Baki, L.; Nafeh, M.; Abdel-Hamid, M.; Strickland, G.T.; Fix, A.D. Hepatitis c in a community in Upper Egypt: risk factors for infection. Am. J. Trop. Med. Hyg., 2002, 66(5), 633-638.
[http://dx.doi.org/10.4269/ajtmh.2002.66.633] [PMID: 12201604]
[13]
Mikhail, N.N.; Lewis, D.L.; Omar, N.; Taha, H.; El-Badawy, A.; Abdel-Mawgoud, N.; Abdel-Hamid, M.; Strickland, G.T. Prospective study of cross-infection from upper-GI endoscopy in a hepatitis C-prevalent population. Gastrointest. Endosc., 2007, 65(4), 584-588.
[http://dx.doi.org/10.1016/j.gie.2006.07.033] [PMID: 17210152]
[14]
Saludes, V.; Esteve, M.; Casas, I.; Ausina, V.; Martró, E. Hepatitis C virus transmission during colonoscopy evidenced by phylogenetic analysis. J. Clin. Virol., 2013, 57(3), 263-266.
[http://dx.doi.org/10.1016/j.jcv.2013.03.007] [PMID: 23567025]
[15]
Van Remoortel, H.; Borra, V.; De Buck, E.; Compernolle, V.; Vandekerckhove, P. Is an endoscopic examination associated with transfusion-transmissible infections? A systematic review and meta-analysis. Transfusion, 2017.
[http://dx.doi.org/10.1111/trf.14416] [PMID: 29194668]

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