[1]
Halfon, P.; Locarnini, S. Hepatitis C virus resistance to protease inhibitors. J. Hepatol., 2011, 55(1), 192-206.
[2]
Genovese, D.; Dettori, S.; Argentini, C.; Villano, U.; Chionne, P.; Angelico, M.; Rapicetta, M. Molecular epidemiology of hepatitis C virus genotype 4 isolates in Egypt and analysis of the variability of envelope proteins E1 and E2 in patients with chronic hepatitis. J. Clin. Microbiol., 2005, 43(4), 1902-1909.
[3]
Bahgat, M.M.; Ibrahim, A.A.; Abd-Elshafy, D.N.; Mesalam, A.A.; Gewaid, H.E.; Ismaeil, A.A.; El-Waseef, A.M.; Maghraby, A.S.; Barakat, A.B.; El-Far, M.A.; Ghanem Hel, D.; Mohamed, A.M.; Ali, M.A. Characterization of NS3 protease from an Egyptian HCV genotype 4a isolate. Arch. Virol., 2009, 154(10), 1649-1657.
[4]
Yang, P.L.; Gao, M.; Lin, K.; Liu, Q.; Villareal, V.A. Anti-HCV drugs in the pipeline. Curr. Opin. Virol., 2011, 1(6), 607-616.
[5]
Das, D.; Hong, J.; Chen, S.H.; Wang, G.; Beigelman, L.; Seiwert, S.D.; Buckman, B.O. Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors. Bioorg. Med. Chem., 2011, 19(16), 4690-4703.
[6]
De Francesco, R.; Carfí, A. Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus. Adv. Drug Deliv. Rev., 2007, 59(12), 1242-1262.
[7]
De Francesco, R.; Tomei, L.; Altamura, S.; Summa, V.; Migliaccio, G. Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase. Antiviral Res., 2003, 58(1), 1-16.
[8]
Gonzalez-Grande, R.; Jimenez-Perez, M.; Gonzalez Arjona, C.; Mostazo Torres, J. New approaches in the treatment of hepatitis C. World J. Gastroenterol., 2016, 22(4), 1421-1432.
[9]
Asselah, T. Daclatasvir plus sofosbuvir for HCV infection: an oral combination therapy with high antiviral efficacy. J. Hepatol., 2014, 61(2), 435-438.
[10]
Lemon, S.M.; McKeating, J.A.; Pietschmann, T.; Frick, D.N.; Glenn, J.S.; Tellinghuisen, T.L.; Symons, J.; Furman, P.A. Development of novel therapies for hepatitis C. Antiviral Res., 2010, 86(1), 79-92.
[11]
Sarrazin, C.; Hézode, C.; Zeuzem, S.; Pawlotsky, J-M. Antiviral strategies in hepatitis C virus infection. J. Hepatol., 2012, 56, S88-S100.
[12]
Yan, S.; Appleby, T.; Larson, G.; Wu, J.Z.; Hamatake, R.; Hong, Z.; Yao, N. Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors. Bioorg. Med. Chem. Lett., 2006, 16(22), 5888-5891.
[13]
Yan, S.; Larson, G.; Wu, J.Z.; Appleby, T.; Ding, Y.; Hamatake, R.; Hong, Z.; Yao, N. Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure. Bioorg. Med. Chem. Lett., 2007, 17(1), 63-67.
[14]
Graham, D.J.; Stahlhut, M.; Flores, O.; Olsen, D.B.; Hazuda, D.J.; LaFemina, R.L.; Ludmerer, S.W. A genotype 2b NS5B polymerase with novel substitutions supports replication of a chimeric HCV 1b:2b replicon containing a genotype 1b NS3-5A background. Antiviral Res., 2006, 69(1), 24-30.
[15]
Elfiky, A.A.; Elshemey, W.M. IDX-184 is a superior HCV direct-acting antiviral drug: a QSAR study. Med. Chem. Res., 2016, 25, 1005-1008.
[16]
Elfiky, A.A.; Elshemey, W.M.; Gawad, W.A. 2′-Methylguanosine Prodrug (IDX-184), Phosphoramidate Prodrug (Sofosbuvir), Diisobutyryl Prodrug (R7128) Are Better Than Their Parent Nucleotides and Ribavirin in Hepatitis C Virus Inhibition: A Molecular Modeling Study. J. Comput. Theor. Nanosci., 2015, 12(3), 376-386.
[17]
Elfiky, A.A. Zika viral polymerase inhibition using anti-HCV drugs both in market and under clinical trials. J. Med. Virol., 2016, 88, 2044-2051.
[18]
Saleh, N.A.; Elfiky, A.A.; Ezat, A.A.; Elshemey, W.M.; Ibrahim, M. The Electronic and quantitative structure activity relationship properties of modified telaprevir compounds as hcv ns3 protease inhibitors. J. Comput. Theor. Nanosci., 2014, 11(2), 544-548.
[19]
Saleh, N.A.; Ezat, A.A.; Elfiky, A.A.; Elshemey, W.M.; Ibrahim, M. Theoretical study on modified boceprevir compounds as ns3 protease inhibitors. J. Comput. Theor. Nanosci., 2015, 12(3), 371-375.
[20]
Raj, V.S.; Osterhaus, A.D.; Fouchier, R.A.; Haagmans, B.L. MERS: Emergence of a novel human coronavirus. Curr. Opin. Virol., 2014, 5, 58-62.
[21]
Elfiky, A.A.; Elshemey, W.M.; Gawad, W.A.; Desoky, O.S. Molecular modeling comparison of the performance of NS5b polymerase inhibitor (PSI-7977) on prevalent HCV genotypes. Protein J., 2013, 32(1), 75-80.
[22]
Schmitz, C.; Bonvin, A.M. Protein-protein HADDocking using exclusively pseudocontact shifts. J. Biomol. NMR, 2011, 50(3), 263-266.
[23]
Zhou, X.J.; Pietropaolo, K.; Chen, J.; Khan, S.; Sullivan-Bolyai, J.; Mayers, D. Safety and pharmacokinetics of IDX184, a liver-targeted nucleotide polymerase inhibitor of hepatitis C virus, in healthy subjects. Antimicrob. Agents Chemother., 2011, 55(1), 76-81.
[24]
Licia Tomei, S.A. Giacomo Paonessa, Raffaele De Francesco and Giovanni Migliaccio, HCV antiviral resistance: the impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase. Antivir. Chem. Chemother., 2005, 16, 225-245.
[25]
Saleh, N.A. The QSAR and docking calculations of fullerene derivatives as HIV-1 protease inhibitors. Spectrochim. Acta A Mol. Biomol. Spectrosc., 2014, 136PC, 1523-1529.
[26]
Elfiky, A.A.; Gawad, W.A.; Elshemey, W.M. Hepatitis C Viral
Polymerase Inhibition using Directly Acting Antivirals, A Computational
Approach. In Software and Techniques for Bio-Molecular
Modeling, A, M., Ed. Austin publishing group: USA, In press.
[27]
Summers, K.L.; Mahrok, A.K.; Dryden, M.D.; Stillman, M.J. Structural properties of metal-free apometallothioneins. Biochem. Biophys. Res. Commun., 2012, 425(2), 485-492.
[28]
O’Farrell, D.; Trowbridge, R.; Rowlands, D.; Jäger, J. Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): Structural evidence for nucleotide import and de-novo initiation. J. Mol. Biol., 2003, 326(4), 1025-1035.
[29]
Harrus, D.; Ahmed-El-Sayed, N.; Simister, P.C.; Miller, S.; Triconnet, M.; Hagedorn, C.H.; Mahias, K.; Rey, F.A.; Astier-Gin, T.; Bressanelli, S. Further insights into the roles of GTP and the C terminus of the hepatitis C virus polymerase in the initiation of RNA synthesis. J. Biol. Chem., 2010, 285(43), 32906-32918.
[30]
Cretton-Scott, E.; Perigaud, C.; Peyrottes, S.; Licklider, L.; Camire, M.; Larsson, M.; La Colla, M.; Hildebrand, E.; Lallos, L.; Bilello, J. 588 in vitro antiviral activity and pharmacology of IDX184, a novel and potent inhibitor of HCV replication. J. Hepatol., 2008, 48, S220.
[31]
Stedman, C. Sofosbuvir, a NS5B polymerase inhibitor in the treatment of hepatitis C: a review of its clinical potential. Therap. Adv. Gastroenterol., 2014, 7(3), 131-140.
[32]
Naka, K.; Ikeda, M.; Abe, K-i.; Dansako, H.; Kato, N. Mizoribine inhibits hepatitis C virus RNA. Biophys. Res. Commun., 2005, 330(3), 871-879.
[33]
Harrus, D.; Ahmed-El-Sayed, N.; Simister, P.C.; Miller, S.; Triconnet, M.; Hagedorn, C.H.; Mahias, K.; Rey, F.A.; Astier-Gin, T.; Bressanelli, S. Further insights into the roles of GTP and the C terminus of the hepatitis C virus polymerase in the initiation of RNA synthesis. J. Biol. Chem., 2010, 285(43), 32906-32918.
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