Abstract
Background: A versatile, facile, one-pot multi-component protocol for the synthesis of 4Hbenzochromenes using L- valine as organocatalyst in aqueous medium has been developed.
Methods: Superior catalytic performance of L- valine, operational simplicity, easy workup procedure and recyclability of the catalyst are the key strengths of reported strategy.
Results: Therefore, it is a green alternative to the existing protocols.
Conclusion: This method offers mild reaction conditions, the use of easily available cheap reagents, short reaction times, excellent yields and high atom economy.
Keywords: L- valine, amino acid, multicomponent, 4H- Benzochromenes, water, organocatalyst.
Graphical Abstract
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