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ISSN (Print): 2213-2759
ISSN (Online): 1874-4796

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Research Article

Identification of Essential Proteins in Yeast Using Mean Weighted Average and Recursive Feature Elimination

Author(s): Sivagnanam Rajamanickam Mani Sekhar*, Siddesh Gaddadevara Matt, Sunilkumar S. Manvi and Srinivasa Krishnarajanagar Gopalalyengar

Volume 12, Issue 1, 2019

Page: [5 - 10] Pages: 6

DOI: 10.2174/2213275911666180918155521

Price: $65

Abstract

Background: Essential proteins are significant for drug design, cell development, and for living organism survival. A different method has been developed to predict essential proteins by using topological feature, and biological features.

Objective: Still it is a challenging task to predict essential proteins effectively and timely, as the availability of protein protein interaction data depends on network correctness.

Methods: In the proposed solution, two approaches Mean Weighted Average and Recursive Feature Elimination is been used to predict essential proteins and compared to select the best one. In Mean Weighted Average consecutive slot data to be taken into aggregated count, to get the nearest value which considered as prescription for the best proteins for the slot, where as in Recursive Feature Elimination method whole data is spilt into different slots and essential protein for each slot is determined.

Results: The result shows that the accuracy using Recursive Feature Elimination is at-least nine percentages superior when compared to Mean Weighted Average and Betweenness centrality.

Conclusion: Essential proteins are made of genes which are essential for living being survival and drug design. Different approaches have been proposed to anticipate essential proteins using either experimental or computation methods. The experimental result show that the proposed work performs better than other approaches.

Keywords: Proteins, essential proteins, weighted average, recursive feature elimination, machine learning, yeast, PPI, proteinprotein interaction.

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