An Efficient Ligandless Palladium-catalyzed Protocol for Suzuki-Miyaura Coupling Reaction of Potassium Aryltrifluoroborates in Water

Title:An Efficient Ligandless Palladium-catalyzed Protocol for Suzuki-Miyaura Coupling Reaction of Potassium Aryltrifluoroborates in Water

Volume: 22 Issue: 20

Author(s): Leifang Liu*, Mingcheng Liu, Jianhua Yang, Baoyong Zhu and Xinfang Wang*

Affiliation:

• Key Laboratory of Coordination Chemistry and Functional Materials in Universities of Shandong, Dezhou University, Dezhou 253023,China

• Key Laboratory of Coordination Chemistry and Functional Materials in Universities of Shandong, Dezhou University, Dezhou 253023,China

Keywords: Suzuki-Miyaura coupling reaction, potassium aryltrifluoroborate, aryl bromide, heteroaryl bromide, water, palladium acetate.

Abstract: An efficient and ligandless catalytic system was developed for the Suzuki- Miyaura coupling reactions of potassium aryltrifluoroborates in pure water. Using TEAB as additives, Pd(OAc)2 was found to be very efficient for the Suzuki-Miyaura coupling of potassium aryltrifluoroborates with various aryl and heteroaryl bromides in pure water with Na2CO3 as a base, affording the desired products in moderate to excellent yields.

Cite this article as:

Liu Leifang*, Liu Mingcheng, Yang Jianhua, Zhu Baoyong and Wang Xinfang*, An Efficient Ligandless Palladium-catalyzed Protocol for Suzuki-Miyaura Coupling Reaction of Potassium Aryltrifluoroborates in Water, Current Organic Chemistry 2018; 22 (20) . https://dx.doi.org/10.2174/1385272822666180913110957