Abstract
Certain lipids can be dispersed as colloidally stable bilayer fragments (BF) or disks with interesting properties for solubilization and delivery of hydrophobic or amphiphilic drugs. They were first observed and characterized as such in the nineties but remained silent in the literature regarding applications for drug delivery. Only recently their potential for delivery of hydrophobic drugs started to be realized. This review deals with electrostatically or sterically stabilized bilayer fragments which provided excellent solubilization sites for antifungal drugs, acted as drugs themselves against bacteria or fungus, could be loaded with amphiphilic drugs or produced lipid-covered drug particles to be delivered as a synergistic formulation in vivo.
Keywords: Antimicrobial activity, disks, bilayer fragments, synergism, fungicides, lipid capsules for drugs
Current Medicinal Chemistry
Title: Lipid Bilayer Fragments and Disks in Drug Delivery
Volume: 13 Issue: 12
Author(s): Ana M. Carmona-Ribeiro
Affiliation:
Keywords: Antimicrobial activity, disks, bilayer fragments, synergism, fungicides, lipid capsules for drugs
Abstract: Certain lipids can be dispersed as colloidally stable bilayer fragments (BF) or disks with interesting properties for solubilization and delivery of hydrophobic or amphiphilic drugs. They were first observed and characterized as such in the nineties but remained silent in the literature regarding applications for drug delivery. Only recently their potential for delivery of hydrophobic drugs started to be realized. This review deals with electrostatically or sterically stabilized bilayer fragments which provided excellent solubilization sites for antifungal drugs, acted as drugs themselves against bacteria or fungus, could be loaded with amphiphilic drugs or produced lipid-covered drug particles to be delivered as a synergistic formulation in vivo.
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Cite this article as:
Carmona-Ribeiro M. Ana, Lipid Bilayer Fragments and Disks in Drug Delivery, Current Medicinal Chemistry 2006; 13 (12) . https://dx.doi.org/10.2174/092986706776872925
DOI https://dx.doi.org/10.2174/092986706776872925 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |

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