Abstract
The synthesis of various N-acetyl-bis-indole compounds has been achieved by one pot reaction of indole and acid chloride in the presence of silica sulfuric acid as a catalyst under microwave irradiation to moderate yields. The reaction has also been studied with different acid chlorides and solvents.
Keywords: Microwave, solvent free, one pot synthesis, N-acetyl-bis-indoles, dye, chlorides.
Graphical Abstract
(b)Penieres-Carrill, G.; Garcia-Estrada, J.G.; Gutierrez-Ramirez, J.L. lvarez-Toledano, C. Green Chem., 2003, 5, 337.
(b)Chakraborti, A.K.; Roy, S.R.; Kumar, D.; Chopra, P. Green Chem., 2008, 10, 1111-1118.
(c)Wang, S.Y.; Ji, S.J. Synth. Commun., 2008, 38, 1291-1298.
(d)Silveira, C.C.; Mendes, S.R.; Líbero, F.M.; Lenardão, E.J.; Perin, G. Tetrahedron Lett., 2009, 50, 6060-6063.
(e)Praveen, C.; Wilson, S. Y.; Perumal, P.T. Tetrahedron Lett., 2009, 50, 644-647.
(f)Naik, M.A.; Sachdev, D.; Dubey, A. Catal. Commun., 2010, 11, 1148-1153.
(b)Ishii, H.; Murakami, K.K.; Sakurada, E.; Hosoya, K.; Murakami, Y. J. Chem. Soc. Perkin Trans. I, 1988, 8, 2377-2385. (d) Pingaew, R.; Prachayasittikul, S.; Ruchirawat, S.; Prachayasittikul, V. Mol. Divers., 2013, 17, 595-604.
(b)Babu, M.V.M.; Shankar, R.; Reddy, G.R.; Rao, T.S.; Rao, M.V.B.; Raghunadh, A. Tetrahedron Lett., 2016, 57, 5033.
(c)Azimi, S.B.; Azizian, J. Tetrahedron Lett., 2016, 57, 181-184.
(d)Zhang, J.; Zhao, J.; Wang, L.; Liu, J.; Ren, D.; Ma, Y. Tetrahedron, 2016, 72, 936.
(e)Safari, J.; Gandomi-Ravandi, S. J. Mol. Catal. A: Chem., 2013, 371, 135-140.