Neuroprotective Effects of Heat Shock Protein70

Title:Neuroprotective Effects of Heat Shock Protein70

Volume: 17 Issue: 10

Author(s): Fatemeh Mohammadi, Navid Nezafat, Manica Negahdaripour, Fatemeh Dabbagh, Afshin Borhani Haghghi, Sedigheh Kianpour, Mehrzad Banihashemi and Younes Ghasemi*

Affiliation:

• Pharmaceutical Sciences Research Center, Shiraz University of Medical Science, Shiraz,Iran

Keywords: Anti-apoptotic, anti-inflammatory, anti-necrotic, chaperone, heat shock protein, HSP70, stroke.

Abstract: Background & Objective: Heat Shock Proteins (HSPs) increase response to many stresses in cells. Stroke is a neural shock that leads to the destruction of a large number of brain cells, whereas induction and expression of HSPs can decrease the amount of damage, and in some conditions can cure damaged cells. HSP70 family is considered as the most important member of HSPs in normal and stress condition of cells. They are strongly up-regulated by stresses and have protective roles in under stressed cells. Therefore, in this review, we briefly consider the association between HSP70 and stroke. We searched in Pubmed and Scopus databases using the specified keywords and selected the articles based on the certain association between HSP70 and stroke. HSP70 protects cells from damage through a variety of cellular and biochemical processes such as chaperone function, anti-apoptotic, anti-necrotic and anti-inflammatory mechanisms.

Conclusion: Protective effects of HSP70 in neurodegenerative shocks are illustrated in the review, and it can be concluded that the induction of HSP70 in stresses can be considered as a therapeutic factor, although it needs further studies.

Cite this article as:

Mohammadi Fatemeh , Nezafat Navid , Negahdaripour Manica, Dabbagh Fatemeh , Haghghi Borhani Afshin , Kianpour Sedigheh , Banihashemi Mehrzad and Ghasemi Younes *, Neuroprotective Effects of Heat Shock Protein70, CNS & Neurological Disorders - Drug Targets 2018; 17 (10) . https://dx.doi.org/10.2174/1871527317666180827111152