Models of Parkinson’s Disease with Special Emphasis on Drosophila melanogaster

Title:Models of Parkinson’s Disease with Special Emphasis on Drosophila melanogaster

Volume: 17 Issue: 10

Author(s): Ambreen Fatima, Smita Jyoti and Yasir Hasan Siddique*

Affiliation:

• Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh,India

Keywords: Parkinson's disease, models, Drosophila, pathological, neurdegerative disorder, etiology.

Abstract: Background & Objective: Parkinson’s disease is the second most common neurodegenerative disorder affecting more than 1% of the population averaged 60 years of age. The majority of PD cases are sporadic and are probably caused by a combination of risk factors but 5-10% of the PD cases are familial. Due to the high degree of the gene, conservation in humans, mice and insects using an animal model system is a valuable approach to further elucidate the roles of the genes in PD.

Conclusion: The present review highlights the models used to study PD symptoms with special emphasis on Drosophila.

Cite this article as:

Fatima Ambreen , Jyoti Smita and Siddique Hasan Yasir *, Models of Parkinson’s Disease with Special Emphasis on Drosophila melanogaster, CNS & Neurological Disorders - Drug Targets 2018; 17 (10) . https://dx.doi.org/10.2174/1871527317666180820164250