Current Non-viral siRNA Delivery Systems as a Promising Treatment of Skin Diseases

Title:Current Non-viral siRNA Delivery Systems as a Promising Treatment of Skin Diseases

Volume: 24 Issue: 23

Author(s): Juliana Rosa, Isabella Suzuki, Marcelo Kravicz, Angelo Caron, Ana Vitória Pupo, Fabíola Garcia Praça and Maria Vitória Lopes Badra Bentley*

Affiliation:

• School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Avenida do Cafe, s/n, 14040903, Ribeirao Preto, SP,Brazil

Keywords: siRNA, Gene Therapy, skin diseases, nanoparticles, non-viral vectors, drug development.

Abstract: Background: Gene therapy is a new approach to discover and treat many diseases. It has attracted considerable attention from researchers in the last decades. The gene therapy through RNA interference has been considered one of the most recent and revolutionary approaches used in individualized therapy. In the last years, we have witnessed the rapid development in the field of the gene silencing and knockdown by topical siRNA. Its application in gene therapy has become an attractive alternative for drug development.

Methods: This article will address topical delivery of siRNA as a promising treatment for skin disorders. An update on the advances in siRNA-based nanocarriers as a powerful therapeutic strategy for several skin diseases will be discussed giving emphasis on in vitro evaluations.

Results: Through the in-depth review of the literature on the use of siRNAs for skin diseases we realize how widespread this use is. We have also realized that nanoparticles as non-viral vectors are increasingly being explored. Skin diseases where the use of siRNA has been explored most are skin cancer (melanoma and nonmelanoma), psoriasis, vitiligo, dermatitis and leprosy. But we also report here other diseases where the use of siRNA has been growing as acne, alopecia areata, cutaneous leishmaniasis, mycoses, herpes, epidermolysis bullosa and oculocutaneous albinism. Also highlighted, the first clinical trial of siRNA for cutaneous diseases, aimed at Pathyounychia Congenita.

Conclusion: The treatment of skin diseases based on topical delivery of siRNA, which act by inhibiting the expression of target transcripts, offers many potential therapeutic advantages for suppressing genes into the skin.

Cite this article as:

Rosa Juliana , Suzuki Isabella, Kravicz Marcelo , Caron Angelo, Pupo Vitória Ana , Praça Garcia Fabíola and Bentley Vitória Lopes Badra Maria *, Current Non-viral siRNA Delivery Systems as a Promising Treatment of Skin Diseases, Current Pharmaceutical Design 2018; 24 (23) . https://dx.doi.org/10.2174/1381612824666180807120017