Oxidative Stress in Cerebral Small Vessel Disease Dizziness Patients, Basally and After Polyphenol Compound Supplementation

Title:Oxidative Stress in Cerebral Small Vessel Disease Dizziness Patients, Basally and After Polyphenol Compound Supplementation

Volume: 18 Issue: 3

Author(s): L. Ulivi, M. Maccarrone, N. Giannini, E. Ferrari, M.C. Caselli, V. Montano, L. Chico, A. Casani, E. Navari, N. Cerchiai, G. Siciliano, U. Bonuccelli and M. Mancuso*

Affiliation:

• Department of Experimental and Clinical Medicine, Neurological Clinic, Pisa University, Pisa,Italy

Keywords: Leukoaraiosis, cerebral small vessel disease, dizziness, oxidative stress, polyphenols, DHI.

Abstract: Background: Leukoaraiosis (LA) is a common radiological finding in elderly, frequently associated with several clinical disorders, including unexplained dizziness. The pathogenesis of LA is multifactorial, with a dysfunction of cerebral microcirculation resulting in chronic hypoperfusion and tissue loss, with oxidative stress involved in this cascade.

Objective: The aim of this study was to analyse some oxidative stress biomarkers in a cohort of LA patients.

Method: Fifty-five consecutive patients (33 males, median age 75 years) with LA were recruited. In a subgroup of 33 patients with LA and unexplained dizziness, we have then performed an open study to evaluate if 60-day supplementation with a polyphenol compound may modify these biomarkers and influence quality of life, analysed with the Dizziness Handicap Inventory (DHI) scale.

Results: At baseline, blood oxidative stress parameters values were outside normal ranges and compared to matched healthy controls. After the two months supplementation, we observed a significant decrement of advanced oxidation protein products values and a significant improvement of DHI.

Conclusion: Oxidative stress biomarkers may be useful to detect redox imbalance in LA and to provide non-invasive tools to monitor disease status and response to therapy.

Cite this article as:

Ulivi L. , Maccarrone M., Giannini N. , Ferrari E. , Caselli M.C., Montano V. , Chico L. , Casani A. , Navari E. , Cerchiai N. , Siciliano G. , Bonuccelli U. and Mancuso M. *, Oxidative Stress in Cerebral Small Vessel Disease Dizziness Patients, Basally and After Polyphenol Compound Supplementation, Current Molecular Medicine 2018; 18 (3) . https://dx.doi.org/10.2174/1566524018666180720165055