Role of Noncoding RNA in Pulmonary Arterial Hypertension and Potential Drug Therapeutic Target

Title:Role of Noncoding RNA in Pulmonary Arterial Hypertension and Potential Drug Therapeutic Target

Volume: 18 Issue: 12

Author(s): Chi-yuan Zhang, Mo liu, Jia-ming Wan, Ming-qi Gao, Yue Zhang, Muscab Soyan, Huai-Liang Wang and Yang Bai*

Affiliation:

• Department of Clinical Pharmacology, College of Pharmacy, China Medical University, Shenyang,China

Keywords: Pulmonary arterial hypertension, Noncoding RNA, Drugs, miRNA, LncRNA, Network.

Abstract: Pulmonary arterial hypertension (PAH) is a devastating disease without effective drugs available for its treatment. An in-depth exploration of the pathogenesis of PAH, as well as inquiry into potential therapeutic targets, remains an urgent issue. Non-coding RNAs (ncRNAs) have arisen as key players in malignant tumors, cardiovascular diseases and more recently in PAH progression and development. Network pharmacology is a new discipline based on system biology, which can predict potential therapeutic targets in diseases regulated by multiple genes. In this review, we discuss the current knowledge of ncRNAs and network pharmacology regulated genes involved in PAH, as well as the search for potential drug targets for PAH.

Cite this article as:

Zhang Chi-yuan, liu Mo, Wan Jia-ming, Gao Ming-qi, Zhang Yue, Soyan Muscab, Wang Huai-Liang and Bai Yang*, Role of Noncoding RNA in Pulmonary Arterial Hypertension and Potential Drug Therapeutic Target, Current Topics in Medicinal Chemistry 2018; 18 (12) . https://dx.doi.org/10.2174/1568026618666180719162124