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Review Article

脂肪因子在头颈部肿瘤的建立和发展中的作用

卷 26, 期 25, 2019

页: [4726 - 4748] 页: 23

弟呕挨: 10.2174/0929867325666180713154505

价格: $65

摘要

脂肪因子构成由白色脂肪组织（WAT）分泌的蛋白质因子家族，可调节WAT和其他位点的功能。 瘦素，脂联素和抵抗素是存在于血清和唾液中的主要脂肪因子，靶向多种组织和器官，包括血管，肌肉，肝脏和胰腺。 除体重调节外，脂肪因子还影响葡萄糖稳态，炎症，血管生成，细胞增殖和凋亡以及其他重要的细胞程序。 它们已经明确参与了肿瘤的形成和生长，并且在包括头颈部区域在内的一些恶性肿瘤中都观察到脂肪因子和脂肪因子受体表达的失调。 脂肪细胞因子的细胞内作用由多种受体介导，这些受体激活几种信号级联，包括Janus激酶/信号转导和转录激活剂（JAK / STAT途径），磷脂酰肌醇激酶（PI3 / Akt / mTOR）和过氧化物酶体增殖物激活受体（PPAR） ）。 本综述总结了关于脂肪因子家族成员在头颈部癌变中作用的最新知识。 还讨论了脂肪因子的诊断和预后意义及其作为血清和唾液生物标志物的潜在作用。

关键词: 脂肪因子，瘦素，脂联素，头颈癌，口腔鳞状细胞癌，唾液腺肿瘤，甲状腺癌，食道癌

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