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Review Article

噬菌体展示技术中计算方法的发展与应用

卷 26, 期 42, 2019

页: [7672 - 7693] 页: 22

弟呕挨: 10.2174/0929867325666180629123117

价格: $65

摘要

背景：噬菌体展示是一种用于鉴定与多个靶标结合的肽配体的功能强大且用途广泛的技术，该技术已成功应用于各种领域，例如诊断和治疗，药物递送和材料科学。下一代测序技术与噬菌体展示相结合，使这种方法更具生产力。随着该技术的广泛使用和噬菌体展示数据的快速积累，这些数据的数据库和计算方法已成为该社区不可或缺的部分。这篇综述旨在总结和讨论在噬菌体展示领域计算方法的开发和应用方面的最新进展。 方法：我们通过Google Scholar和PubMed对噬菌体展示数据的生物信息学资源和计算方法进行了全面搜索。方法和工具根据用途进一步分为不同的类别。 结果：我们描述了七个专门或相关的噬菌体展示数据数据库，这些数据库为噬菌体展示研究人员清理生物淘选结果提供了循证依据。这些数据库可以识别并报告可能的靶标无关肽（TUP），从而从噬菌体展示筛选实验获得的肽中排除假阳性数据。还审查了20多种分析生物淘选数据的计算方法。这些方法分类为报告TUP，预测表位和分析下一代噬菌体展示数据的计算方法。 结论：这里回顾的当前生物信息学档案，方法和工具使生物淘选界受益。为了开发更好的或新的计算工具，还讨论了一些有希望的方向。

关键词: 噬菌体展示，模拟表位，靶标无关肽，下一代测序，表位预测，计算方法，数据库。

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