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Review Article

氧化应激对甘油醛-3-磷酸脱氢酶催化和非糖酵解功能的影响

卷 27, 期 13, 2020

页: [2040 - 2058] 页: 19

弟呕挨: 10.2174/0929867325666180530101057

价格: $65

摘要

背景: Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) is a unique enzyme that, besides its main function in glycolysis （催化甘油醛-3-磷酸氧化），具有许多非糖酵解活性。本综述总结了有关氧化应激在GAPDH酶活性和非糖酵解功能调节中的作用的信息。 方法：基于文献数据分析和我们研究小组的研究结果，提出了通过酶活性位点巯基氧化来调节GAPDH功能的机制。 结果：GAPDH氧化的机制包括将催化性半胱氨酸（Cys150）连续氧化为亚磺酸，亚磺酸和磺酸衍生物，从而导致该酶完全失活。半胱氨酸亚磺酸与还原型谷胱甘肽（GSH）反应形成混合的二硫键（S-谷胱甘肽化的GAPDH），进一步与Cys154反应，在酶的活性位点产生二硫键。与亚磺酸和磺酸相反，混合的二硫键和分子内二硫键是可逆的氧化产物，可在GSH或硫氧还蛋白存在下还原。 结论：由于Cys150的反应性增强，不可避免地要氧化GAPDH活性位上的巯基。 Cys150的不可逆氧化可通过谷胱甘肽化和与Cys154的二硫键来防止。 GAPDH活性位点中巯基的氧化/还原可用于调节糖酵解和该酶的许多副作用，包括诱导细胞凋亡。

关键词: 3-磷酸甘油醛脱氢酶，巯基基团，氧化，S-亚硝基化，S-谷胱甘肽化，氧化应激。

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