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Review Article

炎症的代谢途径：柠檬酸盐途径及其作为治疗靶点的潜力

卷 26, 期 40, 2019

页: [7104 - 7116] 页: 13

弟呕挨: 10.2174/0929867325666180510124558

价格: $65

摘要

炎症中发生重要的代谢变化，以响应细胞的新的能量需求。线粒体不仅用于产生ATP，而且还用于提供底物，例如柠檬酸盐，以产生促炎分子。在这种情况下，大多数柠檬酸盐从克雷布斯循环转移并进入“柠檬酸盐途径”，从而导致线粒体柠檬酸盐载体（CIC）将柠檬酸盐输出到细胞质中，然后将其裂解为乙酰辅酶A和草酰乙酸。由ATP柠檬酸盐裂解酶裂解（ACLY）。乙酰辅酶A用于生产PGE2和草酰乙酸，以生产NO和ROS生产所需的NADPH。另外，胞质柠檬酸盐也提供衣康酸酯合成的前体。柠檬酸盐衍生的衣康酸酯通过调节炎性介质的合成而充当炎症的负调节剂。不同合成和天然分子对CIC或ACLY的抑制作用会导致NO，ROS和PGE2水平的降低，这表明柠檬酸途径可能是炎症中需要解决的新目标。在唐氏综合症中观察到的氧化应激和炎性疾病中也可以获得有益效果。

关键词: 柠檬酸盐途径，线粒体柠檬酸盐载体，ATP柠檬酸盐裂解酶，炎症，抑制作用，ROS，NO，PGE2。

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