Synthesis and Antitumor Activity Evaluation of 2-Aminothiazoles Appended 5-methylisoxazoline and Pyridine-piperazine Hybrid Molecules

Title:Synthesis and Antitumor Activity Evaluation of 2-Aminothiazoles Appended 5-methylisoxazoline and Pyridine-piperazine Hybrid Molecules

Volume: 15 Issue: 12

Author(s): Garbapu Suresh*, Ratnakaram Venkata Nadh, Navuluri Srinivasu and Durgaprasad Yennity

Affiliation:

• Division of Chemistry, Department of Science and Humanities, Vignan's Foundation for Science Technology and Research University, Guntur-522213,India

Keywords: Hybrid drugs, antiproliferative activity, 2-aminothiazole, pyridine-piperazine scaffold, 5-methylisoxazoline, anticancer drug.

Abstract: A highly efficient and milder protocol for the syntheses of novel series of 2-aminothiazoles bearing 5-methylisoxazoline and pyridine-piperazine hybrid molecules has been developed. The target compounds 13a-e were screened for their in vitro cytotoxicity activity against various tumor cell lines including MCF-7 (human breast adenocarcinoma), HCT-116 (colorectal carcinoma), Jurkat (human T-cell leukemia) and THP-1 (human acute monocytic leukemia). The bioactive assay showed that the most of the new compounds exhibited promising results in comparison with the parental Sunitinib. The synthesized compounds could well be used in the future as lead anticancer drugs in drug development studies. The synthesized compounds were fully characterized by IR, 1H NMR, 13C NMR, elemental analysis and mass spectral data.

Cite this article as:

Suresh Garbapu*, Nadh Venkata Ratnakaram , Srinivasu Navuluri and Yennity Durgaprasad, Synthesis and Antitumor Activity Evaluation of 2-Aminothiazoles Appended 5-methylisoxazoline and Pyridine-piperazine Hybrid Molecules, Letters in Organic Chemistry 2018; 15 (12) . https://dx.doi.org/10.2174/1570178615666180430122641