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Review Article

类黄酮与血小板溶解性血栓性疾病

卷 26, 期 39, 2019

页: [7035 - 7047] 页: 13

弟呕挨: 10.2174/0929867325666180417170218

价格: $65

摘要

血栓形成疾病的特征使形成不必要的血栓的可能性增加，这可能是由于凝血级联反应或循环血小板的激活所致。血小板或血小板在止血中起重要作用，但血小板功能异常会导致许多心血管并发症的发展，包括血栓形成疾病。在病理情况下，血小板与各种血栓形成疾病的发展有关，包括动脉粥样硬化，动脉血栓形成和中风，深静脉血栓形成和肺栓塞。因此，血小板是许多抗血栓形成策略的目标。黄酮类化合物是在水果和蔬菜中普遍存在的大量多酚类物质，由于它们对人类健康有益，包括降低心血管疾病的风险，因此引起了广泛关注。据报道，类黄酮可通过减弱激动剂诱导的GPIIb / IIIa受体激活，细胞内游离Ca2 +的动员，颗粒胞吐作用以及不同信号分子（如促分裂原激活的蛋白激酶或磷脂酶）的激活来降低血小板活性。这篇综述总结了有关黄酮调节血小板活化的最新研究，特别关注与血栓形成疾病有关的事件。

关键词: 血小板，血栓性疾病，类黄酮，心血管疾病，GPIIb / IIIa受体，抗血栓形成策略。

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