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Review Article

治疗查加斯病的多药理学

卷 26, 期 23, 2019

页: [4476 - 4489] 页: 14

弟呕挨: 10.2174/0929867325666180410101728

价格: $65

摘要

恰加斯病的当前治疗基于单药理学，其中所使用的药物具有有限的功效和严重的副作用。 为了克服这些局限性，已经描述了一些工具，包括开发或分离新药，药物重新定位和多药理学。 在这里，我们审查了多药理学策略，其中组合了属于不同结构化学型的化合物，以影响克氏锥虫寄生虫的不同生化途径。 因此，将麦角固醇生物合成抑制剂，抗炎药，心脏功能障碍药物，锥虫硫磷还原酶抑制剂，维生素等结合起来，寻找新的抗南美锥虫病治疗方法。 天然产物也用于该策略的应用中。

关键词: 查加斯病，多元药理，协同作用，拮抗作用，等效线图，心功能不全药物。

« Previous
[1]
Nouvellet, P.; Cucunubá, Z.M.; Gourbière, S. Ecology, evolution and control of Chagas disease: a century of neglected modelling and a promising future. Adv. Parasitol., 2015, 87, 135-191.
[http://dx.doi.org/10.1016/bs.apar.2014.12.004] [PMID: 25765195]
[2]
Kapelusznik, L.; Varela, D.; Montgomery, S.P.; Shah, A.N.; Steurer, F.J.; Rubinstein, D.; Caplivski, D.; Pinney, S.P.; Turker, D.; Factor, S.H. Chagas disease in Latin American immigrants with dilated cardiomyopathy in New York City. Clin. Infect. Dis., 2013, 57(1)e7
[http://dx.doi.org/10.1093/cid/cit199] [PMID: 23537911]
[3]
Bahia, M.T. Diniz, Lde.F.; Mosqueira, V.C. Therapeutical approaches under investigation for treatment of Chagas disease. Expert Opin. Investig. Drugs, 2014, 23(9), 1225-1237.
[http://dx.doi.org/10.1517/13543784.2014.922952] [PMID: 24855989]
[4]
Cerecetto, H.; González, M. Synthetic medicinal chemistry in Chagas’ disease: Compounds at the final stage of “Hit-to-Lead” phase. Pharmaceuticals (Basel), 2010, 3(4), 810-838.
[http://dx.doi.org/10.3390/ph3040810] [PMID: 27713281]
[5]
González, M.; Cerecetto, H. Novel compounds to combat trypanosomatid infections: a medicinal chemical perspective. Expert Opin. Ther. Pat., 2011, 21(5), 699-715.
[http://dx.doi.org/10.1517/13543776.2011.565334] [PMID: 21428846]
[6]
Docampo, R.; Moreno, S.N.J.; Turrens, J.F.; Katzin, A.M.; Gonzalez-Cappa, S.M.; Stoppani, A.O.M. Biochemical and ultrastructural alterations produced by miconazole and econazole in Trypanosoma cruzi. Mol. Biochem. Parasitol., 1981, 3(3), 169-180.
[http://dx.doi.org/10.1016/0166-6851(81)90047-5] [PMID: 6265775]
[7]
Beach, D.H.; Goad, L.J.; Holz, G.G., Jr Effects of ketoconazole on sterol biosynthesis by Trypanosoma cruzi epimastigotes. Biochem. Biophys. Res. Commun., 1986, 136(3), 851-856.
[http://dx.doi.org/10.1016/0006-291X(86)90410-9] [PMID: 3521598]
[8]
Larralde, G.; Vivas, J.; Urbina, J.A. Concentration and time dependence of the effects of ketoconazole on growth and sterol synthesis by Trypanosoma (Schizotrypanum) cruzi epimastigotes. Acta Cient. Venez., 1988, 39(2), 140-146.
[PMID: 3075103]
[9]
Van den Bossche, H.; Willemsens, G.; Cools, W.; Cornelissen, F.; Lauwers, W.F.; van Cutsem, J.M. In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis. Antimicrob. Agents Chemother., 1980, 17(6), 922-928.
[http://dx.doi.org/10.1128/AAC.17.6.922] [PMID: 6250469]
[10]
Urbina, J.A.; Vivas, J.; Ramos, H.; Larralde, G.; Aguilar, Z.; Avilán, L. Alteration of lipid order profile and permeability of plasma membranes from Trypanosoma cruzi epimastigotes grown in the presence of ketoconazole. Mol. Biochem. Parasitol., 1988, 30(2), 185-195.
[http://dx.doi.org/10.1016/0166-6851(88)90111-9] [PMID: 2845268]
[11]
Urbina, J.A.; Lazardi, K.; Aguirre, T.; Piras, M.M.; Piras, R. Antiproliferative synergism of the allylamine SF 86-327 and ketoconazole on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi. Antimicrob. Agents Chemother., 1988, 32(8), 1237-1242.
[http://dx.doi.org/10.1128/AAC.32.8.1237] [PMID: 3056256]
[12]
Lazardi, K.; Urbina, J.A.; de Souza, W. Ultrastructural alterations induced by two ergosterol biosynthesis inhibitors, ketoconazole and terbinafine, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi. Antimicrob. Agents Chemother., 1990, 34(11), 2097-2105.
[http://dx.doi.org/10.1128/AAC.34.11.2097] [PMID: 2073100]
[13]
Maldonado, R.A.; Molina, J.; Payares, G.; Urbina, J.A. Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas’ disease. Antimicrob. Agents Chemother., 1993, 37(6), 1353-1359.
[http://dx.doi.org/10.1128/AAC.37.6.1353] [PMID: 8328786]
[14]
Ryley, J.F.; McGregor, S.; Wilson, R.G. Activity of ICI 195,739--a novel, orally active bistriazole--in rodent models of fungal and protozoal infections. Ann. N. Y. Acad. Sci., 1988, 544, 310-328.
[http://dx.doi.org/10.1111/j.1749-6632.1988.tb40416.x] [PMID: 3214071]
[15]
Urbina, J.A.; Lazardi, K.; Aguirre, T.; Piras, M.M.; Piras, R. Antiproliferative effects and mechanism of action of ICI 195,739, a novel bis-triazole derivative, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi. Antimicrob. Agents Chemother., 1991, 35(4), 730-735.
[http://dx.doi.org/10.1128/AAC.35.4.730] [PMID: 2069379]
[16]
Lazardi, K.; Urbina, J.A.; de Souza, W. Ultrastructural alterations induced by ICI 195,739, a bis-triazole derivative with strong antiproliferative action against Trypanosoma (Schizotrypanum) cruzi. Antimicrob. Agents Chemother., 1991, 35(4), 736-740.
[http://dx.doi.org/10.1128/AAC.35.4.736] [PMID: 2069380]
[17]
Urbina, J.A.; Lazardi, K.; Aguirre, T.; Piras, M.M.; Piras, R. Antiproliferative effects and mechanism of action of ICI 195,739, a novel bis-triazole derivative, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi. Antimicrob. Agents Chemother., 1991, 35(4), 730-735.
[http://dx.doi.org/10.1128/AAC.35.4.730] [PMID: 2069379]
[18]
Araújo, M.S.; Martins-Filho, O.A.; Pereira, M.E.; Brener, Z. A combination of benznidazole and ketoconazole enhances efficacy of chemotherapy of experimental Chagas’ disease. J. Antimicrob. Chemother., 2000, 45(6), 819-824.
[http://dx.doi.org/10.1093/jac/45.6.819] [PMID: 10837436]
[19]
Diniz, Lde. F.; Urbina, J.A.; de Andrade, I.M.; Mazzeti, A.L.; Martins, T.A.F.; Caldas, I.S.; Talvani, A.; Ribeiro, I.; Bahia, M.T. Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments. PLoS Negl. Trop. Dis., 2013, 7(8)e2367
[http://dx.doi.org/10.1371/journal.pntd.0002367] [PMID: 23967360]
[20]
Molina, J.; Martins-Filho, O.; Brener, Z.; Romanha, A.J.; Loebenberg, D.; Urbina, J.A. Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts. Antimicrob. Agents Chemother., 2000, 44(1), 150-155.
[http://dx.doi.org/10.1128/AAC.44.1.150-155.2000] [PMID: 10602737]
[21]
Assíria Fontes Martins, T.; de Figueiredo Diniz, L.; Mazzeti, A.L.; da Silva do Nascimento, A.F.; Caldas, S.; Caldas, I.S.; de Andrade, I.M.; Ribeiro, I.; Bahia, M.T. Benznidazole/itraconazole combination treatment enhances anti-Trypanosoma cruzi activity in experimental Chagas disease. PLoS One, 2015, 10(6)e0128707
[http://dx.doi.org/10.1371/journal.pone.0128707] [PMID: 26076455]
[22]
Urbina, J.A.; Vivas, J.; Visbal, G.; Contreras, L.M. Modification of the sterol composition of Trypanosoma (Schizotrypanum) cruzi epimastigotes by delta 24(25)-sterol methyl transferase inhibitors and their combinations with ketoconazole. Mol. Biochem. Parasitol., 1995, 73(1-2), 199-210.
[http://dx.doi.org/10.1016/0166-6851(95)00117-J] [PMID: 8577328]
[23]
Vivas, J.; Urbina, J.A.; de Souza, W. Ultrastructural alterations in Trypanosoma (Schizotrypanum) cruzi induced by Delta(24(25)) sterol methyl transferase inhibitors and their combinations with ketoconazole. Int. J. Antimicrob. Agents, 1997, 8(1), 1-6.
[http://dx.doi.org/10.1016/S0924-8579(96)00345-7] [PMID: 18611778]
[24]
Florin-Christensen, M.; Florin-Christensen, J.; Garin, C.; Isola, E.; Brenner, R.R.; Rasmussen, L. Inhibition of Trypanosoma cruzi growth and sterol biosynthesis by lovastatin. Biochem. Biophys. Res. Commun., 1990, 166(3), 1441-1445.
[http://dx.doi.org/10.1016/0006-291X(90)91028-Q] [PMID: 2407242]
[25]
Urbina, J.A.; Lazardi, K.; Marchan, E.; Visbal, G.; Aguirre, T.; Piras, M.M.; Piras, R.; Maldonado, R.A.; Payares, G.; de Souza, W. Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies. Antimicrob. Agents Chemother., 1993, 37(3), 580-591.
[http://dx.doi.org/10.1128/AAC.37.3.580] [PMID: 8460926]
[26]
Lira, R.; Contreras, L.M.; Rita, R.M.; Urbina, J.A. Mechanism of action of anti-proliferative lysophospholipid analogues against the protozoan parasite Trypanosoma cruzi: potentiation of in vitro activity by the sterol biosynthesis inhibitor ketoconazole. J. Antimicrob. Chemother., 2001, 47(5), 537-546.
[http://dx.doi.org/10.1093/jac/47.5.537] [PMID: 11328763]
[27]
Bhattacharya, S.K.; Sinha, P.K.; Sundar, S.; Thakur, C.P.; Jha, T.K.; Pandey, K.; Das, V.R.; Kumar, N.; Lal, C.; Verma, N.; Singh, V.P.; Ranjan, A.; Verma, R.B.; Anders, G.; Sindermann, H.; Ganguly, N.K. Phase 4 trial of miltefosine for the treatment of Indian visceral leishmaniasis. J. Infect. Dis., 2007, 196(4), 591-598.
[http://dx.doi.org/10.1086/519690] [PMID: 17624846]
[28]
Luna, K.P.; Hernández, I.P.; Rueda, C.M.; Zorro, M.M.; Croft, S.L.; Escobar, P. In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole. Biomedica, 2009, 29(3), 448-455.
[http://dx.doi.org/10.7705/biomedica.v29i3.15] [PMID: 20436996]
[29]
Santa-Rita, R.M.; Lira, R.; Barbosa, H.S.; Urbina, J.A.; de Castro, S.L. Anti-proliferative synergy of lysophospholipid analogues and ketoconazole against Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae): cellular and ultrastructural analysis. J. Antimicrob. Chemother., 2005, 55(5), 780-784.
[http://dx.doi.org/10.1093/jac/dki087] [PMID: 15790672]
[30]
Andrade, S.G.; Andrade, Z.A.; Sadigursky, M. Combined treatment with a nitrofuranic and a corticoid in experimental Chagas’ disease in the dog. Am. J. Trop. Med. Hyg., 1980, 29(5), 766-773.
[http://dx.doi.org/10.4269/ajtmh.1980.29.766] [PMID: 6776831]
[31]
Rassi, A.; Amato Neto, V.; de Siqueira, A.F.; Ferriolli Filho, F.; Amato, V.S.; Rassi, G.G.; Rassi, Junior, A. Treatment of chronic Chagas’ disease with an association of nifurtimox and corticoid. Rev. Soc. Bras. Med. Trop., 2002, 35(6), 547-550.
[http://dx.doi.org/10.1590/S0037-86822002000600001] [PMID: 12612733]
[32]
Michelin, M.A.; Silva, J.S.; Cunha, F.Q. Inducible cyclooxygenase released prostaglandin mediates immunosuppression in acute phase of experimental Trypanosoma cruzi infection. Exp. Parasitol., 2005, 111(2), 71-79.
[http://dx.doi.org/10.1016/j.exppara.2005.05.001] [PMID: 16009364]
[33]
Hideko Tatakihara, V.L.; Cecchini, R.; Borges, C.L.; Malvezi, A.D.; Graça-de Souza, V.K.; Yamada-Ogatta, S.F.; Rizzo, L.V.; Pinge-Filho, P. Effects of cyclooxygenase inhibitors on parasite burden, anemia and oxidative stress in murine Trypanosoma cruzi infection. FEMS Immunol. Med. Microbiol., 2008, 52(1), 47-58.
[http://dx.doi.org/10.1111/j.1574-695X.2007.00340.x] [PMID: 18031539]
[34]
Santos, E.C.; Novaes, R.D.; Bastos, D.S.S.; Oliveira, J.M.; Penitente, A.R.; Gonçalves, W.G.; Cardoso, S.A.; Talvani, A.; Oliveira, L.L. Modulation of oxidative and inflammatory cardiac response by nonselective 1- and 2-cyclooxygenase inhibitor and benznidazole in mice. J. Pharm. Pharmacol., 2015, 67(11), 1556-1566.
[http://dx.doi.org/10.1111/jphp.12451] [PMID: 26105111]
[35]
Campos-Estrada, C.; Liempi, A.; González-Herrera, F.; Lapier, M.; Kemmerling, U.; Pesce, B.; Ferreira, J.; López-Muñoz, R.; Maya, J.D. Simvastatin and benznidazole-mediated prevention of Trypanosoma cruzi-induced endothelial activation: Role of 15-epi-lipoxin A4 in the action of simvastatin. PLoS Negl. Trop. Dis., 2015, 9(5)e0003770
[http://dx.doi.org/10.1371/journal.pntd.0003770] [PMID: 25978361]
[36]
Benaim, G.; Sanders, J.M.; Garcia-Marchán, Y.; Colina, C.; Lira, R.; Caldera, A.R.; Payares, G.; Sanoja, C.; Burgos, J.M.; Leon-Rossell, A.; Concepcion, J.L.; Schijman, A.G.; Levin, M.; Oldfield, E.; Urbina, J.A. Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole. J. Med. Chem., 2006, 49(3), 892-899.
[http://dx.doi.org/10.1021/jm050691f] [PMID: 16451055]
[37]
Veiga-Santos, P.; Barrias, E.S.; Santos, J.F.C.; de Barros Moreira, T.L.; de Carvalho, T.M.; Urbina, J.A.; de Souza, W. Effects of amiodarone and posaconazole on the growth and ultrastructure of Trypanosoma cruzi. Int. J. Antimicrob. Agents, 2012, 40(1), 61-71.
[http://dx.doi.org/10.1016/j.ijantimicag.2012.03.009] [PMID: 22591838]
[38]
Paniz-Mondolfi, A.E.; Pérez-Alvarez, A.M.; Lanza, G.; Márquez, E.; Concepción, J.L. Amiodarone and itraconazole: a rational therapeutic approach for the treatment of chronic Chagas’ disease. Chemotherapy, 2009, 55(4), 228-233.
[http://dx.doi.org/10.1159/000219436] [PMID: 19451712]
[39]
Planer, J.D.; Hulverson, M.A.; Arif, J.A.; Ranade, R.M.; Don, R.; Buckner, F.S. Synergy testing of FDA-approved drugs identifies potent drug combinations against Trypanosoma cruzi. PLoS Negl. Trop. Dis., 2014, 8(7)e2977
[http://dx.doi.org/10.1371/journal.pntd.0002977] [PMID: 25033456]
[40]
de Paula Costa, G.; Silva, R.R.; Pedrosa, M.C.; Pinho, V.; de Lima, W.G.; Teixeira, M.M.; Bahia, M.T.; Talvani, A. Enalapril prevents cardiac immune-mediated damage and exerts anti-Trypanosoma cruzi activity during acute phase of experimental Chagas disease. Parasite Immunol., 2010, 32(3), 202-208.
[http://dx.doi.org/10.1111/j.1365-3024.2009.01179.x] [PMID: 20398183]
[41]
Penitente, A.R.; Leite, A.L.; de Paula Costa, G.; Shrestha, D.; Horta, A.L.; Natali, A.J.; Neves, C.A.; Talvani, A. Enalapril in combination with benznidazole reduces cardiac inflammation and creatine kinases in mice chronically infected with Trypanosoma cruzi. Am. J. Trop. Med. Hyg., 2015, 93(5), 976-982.
[http://dx.doi.org/10.4269/ajtmh.15-0237] [PMID: 26350447]
[42]
Pereira, I.R.; Vilar-Pereira, G.; Moreira, O.C.; Ramos, I.P.; Gibaldi, D.; Britto, C.; Moraes, M.O.; Lannes-Vieira, J. Pentoxifylline reverses chronic experimental Chagasic cardiomyopathy in association with repositioning of abnormal CD8+ T-cell response. PLoS Negl. Trop. Dis., 2015, 9(3)e0003659
[http://dx.doi.org/10.1371/journal.pntd.0003659] [PMID: 25789471]
[43]
Vilar-Pereira, G.; Resende Pereira, I.; de Souza Ruivo, L.A.; Cruz Moreira, O.; da Silva, A.A.; Britto, C.; Lannes-Vieira, J. Combination chemotherapy with suboptimal doses of benznidazole and pentoxifylline sustains partial reversion of experimental Chagas’ heart disease. Antimicrob. Agents Chemother., 2016, 60(7), 4297-4309.
[http://dx.doi.org/10.1128/AAC.02123-15] [PMID: 27161638]
[44]
Rivarola, H.W.; Fernández, A.R.; Enders, J.E.; Fretes, R.; Gea, S.; Paglini-Oliva, P. Effects of clomipramine on Trypanosoma cruzi infection in mice. Trans. R. Soc. Trop. Med. Hyg., 2001, 95(5), 529-533.
[http://dx.doi.org/10.1016/S0035-9203(01)90029-X] [PMID: 11706667]
[45]
Roufogalis, B.D.; Minocherhomjee, A.M.; Al-Jobore, A. Pharmacological antagonism of calmodulin. Can. J. Biochem. Cell Biol., 1983, 61(8), 927-933.
[http://dx.doi.org/10.1139/o83-118] [PMID: 6138140]
[46]
Benson, T.J.; McKie, J.H.; Garforth, J.; Borges, A.; Fairlamb, A.H.; Douglas, K.T. Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures. Biochem. J., 1992, 286(Pt 1), 9-11.
[http://dx.doi.org/10.1042/bj2860009] [PMID: 1355650]
[47]
Fauro, R.; Lo Presti, S.; Bazán, C.; Baez, A.; Strauss, M.; Triquell, F.; Cremonezzi, D.; Negrete, O.S.; Willhuber, G.C.; Paglini-Oliva, P.; Rivarola, H.W. Use of clomipramine as chemotherapy of the chronic phase of Chagas disease. Parasitology, 2013, 140(7), 917-927.
[http://dx.doi.org/10.1017/S0031182013000103] [PMID: 23534690]
[48]
Gobbi, P.; Baez, A.; Lo Presti, M.S.; Fernández, A.R.; Enders, J.E.; Fretes, R.; Gea, S.; Paglini-Oliva, P.A.; Rivarola, H.W. Association of clomipramine and allopurinol for the treatment of the experimental infection with Trypanosoma cruzi. Parasitol. Res., 2010, 107(5), 1279-1283.
[http://dx.doi.org/10.1007/s00436-010-2002-z] [PMID: 20680335]
[49]
Strauss, M.; Lo Presti, M.S.; Bazán, P.C.; Baez, A.; Fauro, R.; Esteves, B.; Sanchez Negrete, O.; Cremonezzi, D.; Paglini-Oliva, P.A.; Rivarola, H.W. Clomipramine and benznidazole association for the treatment of acute experimental Trypanosoma cruzi infection. Parasitol. Int., 2013, 62(3), 293-299.
[http://dx.doi.org/10.1016/j.parint.2013.02.004] [PMID: 23500720]
[50]
García, M.C.; Ponce, N.E.; Sanmarco, L.M.; Manzo, R.H.; Jimenez-Kairuz, A.F.; Aoki, M.P. Clomipramine and benznidazole act synergistically and ameliorate the outcome of experimental Chagas disease. Antimicrob. Agents Chemother., 2016, 60(6), 3700-3708.
[http://dx.doi.org/10.1128/AAC.00404-16] [PMID: 27067322]
[51]
Soeiro, M.N.; De Souza, E.M.; Stephens, C.E.; Boykin, D.W. Aromatic diamidines as antiparasitic agents. Expert Opin. Investig. Drugs, 2005, 14(8), 957-972.
[http://dx.doi.org/10.1517/13543784.14.8.957] [PMID: 16050790]
[52]
Díaz, M.V.; Miranda, M.R.; Campos-Estrada, C.; Reigada, C.; Maya, J.D.; Pereira, C.A.; López-Muñoz, R. Pentamidine exerts in vitro and in vivo anti Trypanosoma cruzi activity and inhibits the polyamine transport in Trypanosoma cruzi. Acta Trop., 2014, 134, 1-9.
[http://dx.doi.org/10.1016/j.actatropica.2014.02.012] [PMID: 24560964]
[53]
Batista, Dda. G.; Batista, M.M.; de Oliveira, G.M.; Britto, C.C.; Rodrigues, A.C.M.; Stephens, C.E.; Boykin, D.W.; Soeiro, Mde.N. Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo. PLoS One, 2011, 6(7)e22155
[http://dx.doi.org/10.1371/journal.pone.0022155] [PMID: 21814568]
[54]
da Silva, C.F. Batista, Dda.G.; Oliveira, G.M.; de Souza, E.M.; Hammer, E.R.; da Silva, P.B.; Daliry, A.; Araujo, J.S.; Britto, C.; Rodrigues, A.C.; Liu, Z.; Farahat, A.A.; Kumar, A.; Boykin, D.W.; Soeiro, Mde.N. In vitro and in vivo investigation of the efficacy of arylimidamide DB1831 and its mesylated salt form--DB1965--against Trypanosoma cruzi infection. PLoS One, 2012, 7(1)e30356
[http://dx.doi.org/10.1371/journal.pone.0030356] [PMID: 22291940]
[55]
Seguel, V.; Castro, L.; Reigada, C.; Cortes, L.; Díaz, M.V.; Miranda, M.R.; Pereira, C.A.; Lapier, M.; Campos-Estrada, C.; Morello, A.; Kemmerling, U.; Maya, J.D.; López-Muñoz, R. Pentamidine antagonizes the benznidazole’s effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target. Exp. Parasitol., 2016, 171, 23-32.
[http://dx.doi.org/10.1016/j.exppara.2016.10.007] [PMID: 27729250]
[56]
Ciccarelli, A.; Araujo, L.; Batlle, A.; Lombardo, E. Effect of haemin on growth, protein content and the antioxidant defence system in Trypanosoma cruzi. Parasitology, 2007, 134(Pt 7), 959-965.
[http://dx.doi.org/10.1017/S0031182007002399] [PMID: 17316475]
[57]
Ciccarelli, A.B.; Frank, F.M.; Puente, V.; Malchiodi, E.L.; Batlle, A.; Lombardo, M.E. Antiparasitic effect of vitamin B12 on Trypanosoma cruzi. Antimicrob. Agents Chemother., 2012, 56(10), 5315-5320.
[http://dx.doi.org/10.1128/AAC.00481-12] [PMID: 22869565]
[58]
Cristina Desoti, V.; Lazarin-Bidóia, D.; Martins Ribeiro, F.; Cardoso Martins, S.; da Silva Rodrigues, J.H.; Ueda-Nakamura, T.; Vataru Nakamura, C.; Farias Ximenes, V.; de Oliveira Silva, S. The combination of vitamin K3 and vitamin C has synergic activity against forms of Trypanosoma cruzi through a redox imbalance process. PLoS One, 2015, 10(12)e0144033
[http://dx.doi.org/10.1371/journal.pone.0144033] [PMID: 26641473]
[59]
Valdez, R.H.; Tonin, L.T.; Ueda-Nakamura, T.; Dias Filho, B.P.; Morgado-Diaz, J.A.; Sarragiotto, M.H.; Nakamura, C.V. Biological activity of 1,2,3,4-tetrahydro-beta-carboline-3-carboxamides against Trypanosoma cruzi. Acta Trop., 2009, 110(1), 7-14.
[http://dx.doi.org/10.1016/j.actatropica.2008.11.008] [PMID: 19063858]
[60]
Izumi, E.; Morello, L.G.; Ueda-Nakamura, T.; Yamada-Ogatta, S.F.; Filho, B.P.; Cortez, D.A.G.; Ferreira, I.C.P.; Morgado-Díaz, J.A.; Nakamura, C.V. Trypanosoma cruzi: antiprotozoal activity of parthenolide obtained from Tanacetum parthenium (L.) Schultz Bip. (Asteraceae, Compositae) against epimastigote and amastigote forms. Exp. Parasitol., 2008, 118(3), 324-330.
[http://dx.doi.org/10.1016/j.exppara.2007.08.015] [PMID: 17950283]
[61]
Pelizzaro-Rocha, K.J.; Tiuman, T.S.; Izumi, E.; Ueda-Nakamura, T.; Dias Filho, B.P.; Nakamura, C.V. Synergistic effects of parthenolide and benznidazole on Trypanosoma cruzi. Phytomedicine, 2010, 18(1), 36-39.
[http://dx.doi.org/10.1016/j.phymed.2010.09.005] [PMID: 21035317]
[62]
Izumi, E.; Ueda-Nakamura, T.; Veiga, V.F., Jr; Pinto, A.C.; Nakamura, C.V. Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. J. Med. Chem., 2012, 55(7), 2994-3001.
[http://dx.doi.org/10.1021/jm201451h] [PMID: 22440015]
[63]
Sandjo, L.P.; de Moraes, M.H.; Kuete, V.; Kamdoum, B.C.; Ngadjui, B.T.; Steindel, M. Individual and combined antiparasitic effect of six plant metabolites against Leishmania amazonensis and Trypanosoma cruzi. Bioorg. Med. Chem. Lett., 2016, 26(7), 1772-1775.
[http://dx.doi.org/10.1016/j.bmcl.2016.02.044] [PMID: 26906638]
[64]
Francisco, A.F.; de Abreu Vieira, P.M.; Arantes, J.M.; Pedrosa, M.L.; Martins, H.R.; Silva, M.; Veloso, V.M.; de Lana, M.; Bahia, M.T.; Tafuri, W.L.; Carneiro, C.M. Trypanosoma cruzi: effect of benznidazole therapy combined with the iron chelator desferrioxamine in infected mice. Exp. Parasitol., 2008, 120(4), 314-319.
[http://dx.doi.org/10.1016/j.exppara.2008.08.002] [PMID: 18789321]
[65]
Santos, C.D.; Toldo, M.P.; Santello, F.H. Filipin, Mdel.V.; Brazão, V.; do Prado Júnior, J.C. Dehydroepiandrosterone increases resistance to experimental infection by Trypanosoma cruzi. Vet. Parasitol., 2008, 153(3-4), 238-243.
[http://dx.doi.org/10.1016/j.vetpar.2008.01.039] [PMID: 18337011]
[66]
Santos, C.D.; Loria, R.M.; Oliveira, L.G.; Kuehn, C.C.; Toldo, M.P.; Albuquerque, S.; do Prado, J.C. Jr Effects of dehydroepiandrosterone-sulfate (DHEA-S) and benznidazole treatments during acute infection of two different Trypanosoma cruzi strains. Immunobiology, 2010, 215(12), 980-986.
[http://dx.doi.org/10.1016/j.imbio.2009.11.002] [PMID: 20163889]
[67]
Wen, J-J.; Gupta, S.; Guan, Z.; Dhiman, M.; Condon, D.; Lui, C.; Garg, N.J. Phenyl-α-tert-butyl-nitrone and benzonidazole treatment controlled the mitochondrial oxidative stress and evolution of cardiomyopathy in chronic chagasic Rats. J. Am. Coll. Cardiol., 2010, 55(22), 2499-2508.
[http://dx.doi.org/10.1016/j.jacc.2010.02.030] [PMID: 20510218]
[68]
Pérez-Silanes, S.; Torres, E.; Arbillaga, L.; Varela, J.; Cerecetto, H.; González, M.; Azqueta, A.; Moreno-Viguri, E. Synthesis and biological evaluation of quinoxaline di-N-oxide derivatives with in vitro trypanocidal activity. Bioorg. Med. Chem. Lett., 2016, 26(3), 903-906.
[http://dx.doi.org/10.1016/j.bmcl.2015.12.070] [PMID: 26750255]
[69]
Rodrigues, J.H.; Ueda-Nakamura, T.; Corrêa, A.G.; Sangi, D.P.; Nakamura, C.V. A quinoxaline derivative as a potent chemotherapeutic agent, alone or in combination with benznidazole, against Trypanosoma cruzi. PLoS One, 2014, 9(1)e85706
[http://dx.doi.org/10.1371/journal.pone.0085706] [PMID: 24465654]
[70]
Santos, E.C.; Novaes, R.D.; Cupertino, M.C.; Bastos, D.S.S.; Klein, R.C.; Silva, E.A.M.; Fietto, J.L.R.; Talvani, A.; Bahia, M.T.; Oliveira, L.L. Chemotherapy with Benznidazole and Suramin: applicability of their concomitant treatment in mice infected with a virulent strain of Trypanosoma cruzi. Antimicrob. Agents Chemother., 2015, 59, 5999-6006.
[http://dx.doi.org/10.1128/AAC.00779-15] [PMID: 26169419]
[71]
Novaes, R.D.; Sartini, M.V.P.; Rodrigues, J.P.F.; Gonçalves, R.V.; Santos, E.C.; Souza, R.L.M.; Caldas, I.S. Curcumin enhances the anti-Trypanosoma cruzi activity of benznidazole-based chemotherapy in acute experimental Chagas disease. Antimicrob. Agents Chemother., 2016, 60(6), 3355-3364.
[http://dx.doi.org/10.1128/AAC.00343-16] [PMID: 27001816]
[72]
Faúndez, M.; Pino, L.; Letelier, P.; Ortiz, C.; López, R.; Seguel, C.; Ferreira, J.; Pavani, M.; Morello, A.; Maya, J.D. Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi. Antimicrob. Agents Chemother., 2005, 49(1), 126-130.
[http://dx.doi.org/10.1128/AAC.49.1.126-130.2005] [PMID: 15616285]
[73]
Faúndez, M.; López-Muñoz, R.; Torres, G.; Morello, A.; Ferreira, J.; Kemmerling, U.; Orellana, M.; Maya, J.D. Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas’ disease and enhances the efficacy of nifurtimox. Antimicrob. Agents Chemother., 2008, 52(5), 1837-1839.
[http://dx.doi.org/10.1128/AAC.01454-07] [PMID: 18332173]
[74]
Cencig, S.; Coltel, N.; Truyens, C.; Carlier, Y. Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains. Int. J. Antimicrob. Agents, 2012, 40(6), 527-532.
[http://dx.doi.org/10.1016/j.ijantimicag.2012.08.002] [PMID: 23063742]
[75]
Kuehn, C.C.; Rodrigues Oliveira, L.G.; Santos, C.D.; Ferreira, D.S.; Alonso Toldo, M.P.; de Albuquerque, S.; do Prado, J.C., Jr Melatonin and dehydroepiandrosterone combination: does this treatment exert a synergistic effect during experimental Trypanosoma cruzi infection? J. Pineal Res., 2009, 47(3), 253-259.
[http://dx.doi.org/10.1111/j.1600-079X.2009.00708.x] [PMID: 19732300]
[76]
Oliveira, L.G.R.; Kuehn, C.C.; Santos, C.D.; Toldo, M.P.A.; do Prado, J.C. Jr Enhanced protection by melatonin and meloxicam combination in experimental infection by Trypanosoma cruzi. Parasite Immunol., 2010, 32(4), 245-251.
[http://dx.doi.org/10.1111/j.1365-3024.2009.01185.x] [PMID: 20398224]
[77]
Fieck, A.; Hurwitz, I.; Kang, A.S.; Durvasula, R. Trypanosoma cruzi: synergistic cytotoxicity of multiple amphipathic anti-microbial peptides to T. cruzi and potential bacterial hosts. Exp. Parasitol., 2010, 125(4), 342-347.
[http://dx.doi.org/10.1016/j.exppara.2010.02.016] [PMID: 20206169]
[78]
Veiga-Santos, P.; Li, K.; Lameira, L.; de Carvalho, T.M.; Huang, G.; Galizzi, M.; Shang, N.; Li, Q.; Gonzalez-Pacanowska, D.; Hernandez-Rodriguez, V.; Benaim, G.; Guo, R.T.; Urbina, J.A.; Docampo, R.; de Souza, W.; Oldfield, E. SQ109, a new drug lead for Chagas disease. Antimicrob. Agents Chemother., 2015, 59(4), 1950-1961.
[http://dx.doi.org/10.1128/AAC.03972-14] [PMID: 25583723]
[79]
Morillo, C.A.; Waskin, H.; Sosa-Estani, S.; Del Carmen Bangher, M.; Cuneo, C.; Milesi, R.; Mallagray, M.; Apt, W.; Beloscar, J.; Gascon, J.; Molina, I.; Echeverria, L.E.; Colombo, H.; Perez-Molina, J.A.; Wyss, F.; Meeks, B.; Bonilla, L.R.; Gao, P.; Wei, B.; McCarthy, M.; Yusuf, S. STOP-CHAGAS Investigators. Benznidazole and posaconazole in eliminating parasites in asymptomatic T. cruzi carriers. J. Am. Coll. Cardiol., 2017, 69(8), 939-947.
[http://dx.doi.org/10.1016/j.jacc.2016.12.023] [PMID: 28231946]

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