Genetic and Genomic Strategies in Learning and Memory

Daniel   M.   Sforza; Desmond   J.   Smith

doi:10.2174/1389202033490259

Abstract

Learning and memory is a property of central importance in the nervous system, yet many of the molecular mechanisms for this behavior remain enshrouded in mystery. Despite the daunting nature of the problem, a number of complementary strategies have been employed to unravel the complexities of learning and memory, ranging from genetics to biochemistry. One of the most recent tools brought to bear in this area is genomics. Here, we review some of the most significant insights that have been so far obtained in learning and memory, and we suggest possible areas of future progress.

Keywords: complex traits, down syndrome, engineered mice, expression profiling, functional genomics, genetics, learning and memory, microarrays