Abstract
Background: A novel series of fused imidazole was prepared from the reaction of 2- bromoacetyl-3-phenyl-1,3,4-thiadiazole with various heterocyclic amines under microwave irradiation. The structures of all the novel products were elucidated based on the elemental analysis and spectral data.
Results: In addition, the biological activity of the newly synthesized compounds was evaluated and the results obtained indicate their potency as anti-inflammatory, analgesic and anti- ulcer agents.
Conclusion: The binding mechanism of the most active compounds was studied using MOE to analyze the molecular interactions.
Keywords: 1, 3, 4-thiadiazoles, fused imidazoles, heterocyclic amines, microwave irradiation, anti-inflammatory, analgesic and anti-ulcer agents.
Graphical Abstract
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