跨膜阴离子载体的生物活性

Title:Biological Activity of Trans-Membrane Anion Carriers

Volume: 25 Issue: 30

关键词: 阴离子，离子转运，生物膜，抗生素活性，抗癌活性，囊性纤维化，超分子化学。

摘要: Natural and synthetic anionophores promote the trans-membrane transport of anions such as chloride and bicarbonate. This process may alter cellular homeostasis with possible effects on internal ions concentration and pH levels triggering several and diverse biological effects. In this article, an overview of the recent results on the study of aniontransporters, mainly acting with a carrier-type mechanism, is given with emphasis on the structure/activity relationship and on their biological activity as antibiotic and anticancer agents and in the development of new drugs for treating conditions derived from dysregulation of natural anion channels.

Cite this article as:

Biological Activity of Trans-Membrane Anion Carriers, Current Medicinal Chemistry 2018; 25 (30) . https://dx.doi.org/10.2174/0929867325666180309113222