摘要
癌症患者通常与各种生理和心理症状有关。在缓和的环境下,目的是缓解这些症状,改善生活质量,增加癌症患者的药物依从性。抗抑郁药被普遍接受用于治疗癌症患者的抑郁症。抗抑郁药的一些其他潜在的好处已经在癌症患者中被报道。 目的:本研究旨在回顾抗抑郁药在癌症患者的生理和心理症状中的应用。 结果:我们的研究结果显示,与癌症患者相关的各种症状的阳性和阴性结果是混合的,这些研究是按照从高到低水平的证据层次分类的,即随机对照试验、队列研究、病例对照研究、病例系列、病例报告以及其他类型的证据。大多数用于癌症患者的抗抑郁药物似乎对抑郁症、焦虑、潮热和其他症状如性功能障碍、疲劳、尼古丁依赖、血管运动症状、执行功能、睡眠问题、瘙痒以及疑病症的治疗都是有益的。虽然氟西汀被发现与恩丹西酮的止吐作用减少有关,米氮平被认为是治疗癌症患者恶心和恶病质的良好选择。 结论:有必要进行更多具有足够统计力的研究,以验证癌症患者使用抗抑郁药治疗这些生理和心理症状的有效性。
关键词: 抗抑郁,焦虑,恶心,恶病质,潮热,疼痛,癌症。
图形摘要
Current Drug Targets
Title:The Use of Antidepressants for Physical and Psychological Symptoms in Cancer
Volume: 19 Issue: 12
关键词: 抗抑郁,焦虑,恶心,恶病质,潮热,疼痛,癌症。
摘要: Cancer patients are commonly associated with various physical and psychological symptoms. In palliative setting, the aims are to relieve those symptoms, improve quality of life, and increase medication adherence among cancer patients. Antidepressants are generally accepted for the treatment of depression among patients with or without cancer. Some other potential benefits of the antidepressants have been reported in cancer patients.
Objective: This study aims to review the use of antidepressants for physical and psychological symptoms in cancer patients.
Results: Our findings showed the mixed result of positive and negative findings in various symptoms associated with cancer patients. These studies are categorised according to the hierarchy of evidence from high to low level, namely randomised controlled trials, cohort studies, case-control studies, case series, case reports, as well as other type of publications. The majority of antidepressants used in cancer patients seem to be beneficial for the treatment of depression, anxiety, hot flashes and other symptoms such as sexual dysfunction, fatigue, nicotine dependence, vasomotor symptoms, executive functions, sleep problems, pruritus, as well as for hypochondriasis. While fluoxetine was found to be associated with the reduction of antiemetic property in ondansetron, mirtazapine was identified to be a good alternative in treating nausea and cachexia among cancer patients.
Conclusion: More research studies with adequate statistical power are warranted to validate the use of antidepressants among cancer patients in treating these physical and psychological symptoms.
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Cite this article as:
The Use of Antidepressants for Physical and Psychological Symptoms in Cancer, Current Drug Targets 2018; 19 (12) . https://dx.doi.org/10.2174/1389450119666180226125026
DOI https://dx.doi.org/10.2174/1389450119666180226125026 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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