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Review Article

抗NMDA受体脑炎：对男性患者的治疗功效和miRNA生物标志物

卷 27, 期 24, 2020

页: [4138 - 4151] 页: 14

弟呕挨: 10.2174/0929867325666180221142623

价格: $65

摘要

背景：抗N-甲基-D-天冬氨酸（NMDA）受体脑炎是脑炎的一种急性形式。抗NMDA受体脑炎的治疗方法通常包括类固醇，静脉注射免疫球蛋白，血浆置换，血浆清除，利妥昔单抗，环磷酰胺和肿瘤切除。 目的：我们旨在比较静脉注射免疫球蛋白，血浆置换，血浆清除，利妥昔单抗或环磷酰胺治疗对无肿瘤的男性抗NMDA受体脑炎患者的疗效，并探讨该疾病的潜在生物标志物。 方法：采用Fisher精确检验和列联表分析法对43例男性和76例女性患者的治疗效果进行分析。另外，采用分层树法分析了男性和女性患者治疗效果的差异。 结果：测试男性患者血浆置换的功效率是否大于阈值的p值与其他两种治疗的p值显着不同。此外，分层树法表明，男性和女性患者与早期康复相关的治疗策略是不同的。 结论：结果表明，对于没有肿瘤的男性患者，血浆置换（或血浆清除）的疗效率不逊于静脉注射免疫球蛋白和利妥昔单抗（或环磷酰胺）。另外，吸引B细胞的C-X-C基序趋化因子13（CXCL13）和microRNA let-7b具有成为抗NMDA受体脑炎的治疗反应生物标志物的潜力。除非它们不是其他自身免疫性脑炎的生物标志物，否则它们可能不是该脑炎有用的预后生物标志物。

关键词: 抗NMDA受体脑炎，免疫疗法，有效率，治疗，趋化因子13，microRNA。

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