K+ Channels of Müller Glial Cells in Retinal Disorders

Title:K+ Channels of Müller Glial Cells in Retinal Disorders

Volume: 17 Issue: 4

Author(s): Feng Gao, Lin-Jie Xu, Yuan Zhao, Xing-Huai Sun*Zhongfeng Wang*

Affiliation:

• Department of Ophthalmology at Eye & ENT Hospital, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Shanghai Key Laboratory of Visual Impairment and Restoration, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200031,China

• Department of Ophthalmology at Eye & ENT Hospital, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Shanghai Key Laboratory of Visual Impairment and Restoration, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200031,China

Keywords: A-type K+ channels, BKCa channels, KDR, Kir channels, Müller cells, retinal disorders.

Abstract: Background & Objective: Müller cell is the major type of glial cell in the vertebrate retina. Müller cells express various types of K+ channels, such as inwardly rectifying K+ (Kir) channels, big conductance Ca2+-activated K+ (BKCa) channels, delayed rectifier K+ channels (KDR), and transient A-type K+ channels. These K+ channels play important roles in maintaining physiological functions of Müller cells. Under some retinal pathological conditions, the changed expression and functions of K+ channels may contribute to retinal pathogenesis.

Conclusion: In this article, we reviewed the physiological properties of K+ channels in retinal Müller cells and the functional changes of these channels in retinal disorders.

Cite this article as:

Gao Feng , Xu Lin-Jie , Zhao Yuan, Sun Xing-Huai*, Wang Zhongfeng *, K+ Channels of Müller Glial Cells in Retinal Disorders, CNS & Neurological Disorders - Drug Targets 2018; 17 (4) . https://dx.doi.org/10.2174/1871527317666180202114233