Practical and Efficient Synthesis of Hydroxyaryl Ketones Catalyzed by HF@SiO2 under Solvent-free Condition

Title:Practical and Efficient Synthesis of Hydroxyaryl Ketones Catalyzed by HF@SiO2 under Solvent-free Condition

Volume: 15 Issue: 9

Author(s): Hossein Paghandeh, Hamid Saeidian*Mohammad Ghaffarzadeh

Affiliation:

• Department of Science, Payame Noor University (PNU), PO Box: 19395-4697, Tehran,Iran

Keywords: Fries rearrangement, hydroxyaryl ketones, HF@SiO2, solvent-free condition, selective synthesis, isomer.

Abstract: A wide variety of hydroxyaryl ketones bearing different motifs was successfully synthesized with good yields and excellent selectivities in the presence of HF@SiO2 as an environmental friendly acid under solvent-free condition. Mild and green reaction conditions and excellent yields (50-91%) make this method an attractive method for the efficient synthesis of hydroxyaryl ketones. Fries rearrangement of phenyl benzoate in the presence of HF@SiO2 led to p-hydroxybenzophenone, while phenyl acetate in the same conditions produced o-hydroxyacetophenone as a single isomer.

Cite this article as:

Paghandeh Hossein , Saeidian Hamid *, Ghaffarzadeh Mohammad , Practical and Efficient Synthesis of Hydroxyaryl Ketones Catalyzed by HF@SiO2 under Solvent-free Condition, Letters in Organic Chemistry 2018; 15 (9) . https://dx.doi.org/10.2174/1570178615666180126153924